| TGFβ1对人血管内皮细胞整合素β3及粘着斑激酶表达的影响 |
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| 摘 要： | ![]()
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| 关 键 词： | 血管内皮细胞 转化生长因子β 整合素β3 粘着斑激酶 动脉粥样硬化 |
Effects of transforming growth factor beta 1 on the expression of integrin beta 3 and the activity of focal adhesion kinase on human vascular endothelial cell] |
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| H Fu,X Liu,L Yang,Q Qiang,M Huang. Effects of transforming growth factor beta 1 on the expression of integrin beta 3 and the activity of focal adhesion kinase on human vascular endothelial cell][J]. Journal of West China University of Medical Sciences, 2001, 32(1): 21-23 |
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| Authors: | H Fu X Liu L Yang Q Qiang M Huang |
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| Affiliation: | Department of Cardiology, First Affiliated Hospital, WCUMS, Chengdu 610041, China. |
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| Abstract: | ![]()
OBJECTIVE: To observe the effects of transforming growth factors beta 1 (TGF beta 1) on the expression of integrin beta 3 and the activity of focal adhesion kinase (FAK). METHODS: This study was performed on cultured human endothelial cells (EC) by using cell-ELISA and immunoprecipitation-tyrosine kinase assay respectively. RESULTS: Under the stimulus of TGF beta 1, there a dose-dependent increase in the expression of integrin beta 3 chain in the surface of EC. And after the cultured EC were treated with 5 ng/ml or 10 ng/ml TGF beta 1 for 6 or 24 hours, the FAK activity in EC increased significantly as compared with the control group (P < 0.05). CONCLUSION: The expression of integrin beta 3 and the activity of FAK on EC were regulated by TGF beta 1, and this regulation may be important in cell adherence, angiogenesis, and in the pathophysiology of atherosclerosis. |
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