GnRH-a降调节人工周期冻融胚胎移植后不同黄体支持方案对妊娠结局的影响

目的 分析促性腺激素释放激素激动剂(GnRH-a)降调节人工周期冻融胚胎移植(FET)后不同黄体支持方案对妊娠结局的影响.方法 回顾性分析2018年10月至2019年10月在西北妇女儿童医院生殖中心进行GnRH-a降调节人工周期准备内膜后行FET的746例不孕症患者临床资料.根据移植后黄体支持方案分为3组:黄体酮注射液...

Effects of different luteal support regimen on pregnancy outcome in frozen-thawed embryo transfer of GnRH agonist down-regulation artificial cycle

Objective:To analyze the effect of different luteal support regimen on pregnancy outcomes in frozen-thawed embryo transfer(FET)of GnRH agonist(GnRH-a)down-regulation artificial cycle.Methods:A retrospective analysis of 746 infertile patients who underwent frozen-thawed embryo transfer(FET)after preparation of the endometrium of GnRH-a down-regulation artificial cycle in the Center of Northwest Women’s and Children’s Hospital from October 2018 to October 2019.According to the luteal support regimen after transplantation,they were divided into three groups:group A(progesterone intramuscular injection plus dydrogesterone,n=332),group B(progesterone soft capsule plus dydrogesterone,n=199),group C(progesterone vaginal sustained-release gel plus dydrogesterone,n=215).The general information,transplantation and pregnancy outcome were compared among the three groups.Results:There were no significant differences in age,infertility years,body mass index,endometrial thickness on transplantation day and the number of embryos transferred among the three groups(P>0.05).The implantation rate,clinical pregnancy rate,ectopic pregnancy rate,multiple pregnancy rate,ectopic pregnancy rate,early miscarriage rate and live birth rate among the three groups were not significantly different(P>0.05).There was no significant difference in the delivery methods,days of pregnancy,birth weight among the three groups(P>0.05).Conclusions:Different dosage and forms of progesterone combined with progesterone for luteal support did not affect the pregnancy outcome of patients undergoing FET in GnRH-a down regulation artificial cycle.Therefore,in the clinician can choose a suitable corpus luteum support regimen according to the patient’s acceptance and economic conditions.