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Reaction to the paper: Interaction of Polysorbate 80 with Erythropoietin: A Case Study in Protein–Surfactant Interactions |
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| Authors: | Suzanne Hermeling Wim Jiskoot Daan J. A. Crommelin Huub Schellekens |
| Affiliation: | (1) Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands;(2) Department of Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands |
| Abstract: | Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure. |
| Keywords: | epoetin Eprex immunogenicity micelles polysorbate 80 |
| 本文献已被 SpringerLink 等数据库收录！ | |