| 瑞舒伐他汀对颈动脉粥样硬化患者血脂和颈动脉斑块的影响 |
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| 引用本文： | 高丽君,齐晓勇,王秀萍,高俊茶,蔺杰. 瑞舒伐他汀对颈动脉粥样硬化患者血脂和颈动脉斑块的影响[J]. 中国全科医学, 2011, 14(36) |
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| 作者姓名： | 高丽君 齐晓勇 王秀萍 高俊茶 蔺杰 |
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| 作者单位： | 河北省人民医院心内科,河北省石家庄市,050051 |
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| 基金项目： | 河北省科学技术研究与发展计划项目(08276101D-102) |
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| 摘 要： | 目的探讨颈动脉粥样硬化患者应用瑞舒伐他汀药物治疗对血脂水平及颈动脉粥样硬化斑块厚度及稳定性的影响。方法选择我院2008年1月—2009年12月门诊及体检中心,经颈动脉彩色超声证实有颈动脉斑块,自愿参加临床观察的40例患者作为观察对象,随机分为治疗组和对照组,各20例。治疗组给予瑞舒伐他汀10 mg/d,合并应用肠溶阿司匹林75 mg/d,对照组给予肠溶阿司匹林75 mg/d。并根据病情给予降压、降糖等药物,两组均进行饮食控制。观察治疗前、治疗后12个月两组血脂水平及颈动脉斑块总数、斑块厚度及斑块性质的变化,并记录两组终点事件的发生情况。结果 (1)治疗组服用瑞舒伐他汀12个月后,血清总胆固醇(TC)水平由(4.93±1.12)mmol/L降至(3.80±0.98)mmol/L,低密度脂蛋白胆固醇(LDL-C)水平由(3.80±1.73)mmol/L降为(2.38±1.18)mmol/L(P<0.05);高密度脂蛋白胆固醇(HDL-C)和三酰甘油(TG)水平与用药前比较,差异无统计学意义(P>0.05)。对照组观察期内各项血脂指标无明显变化(P>0.05)。(2)治疗组患者治疗前后斑块数未见明显变化,斑块的厚度...
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| 关 键 词： | 瑞舒伐他汀 动脉粥样硬化斑块 颈动脉狭窄 |
The Influences of Rosuvastatin on Hyperlipidemia and Carotid Artery Plaques in Patients with Carotid Atherosclerosis |
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| GAO Li-jun,QI Xiao-yong,WANG Xiu-ping,et al.. The Influences of Rosuvastatin on Hyperlipidemia and Carotid Artery Plaques in Patients with Carotid Atherosclerosis[J]. Chinese General Practice, 2011, 14(36) |
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| Authors: | GAO Li-jun QI Xiao-yong WANG Xiu-ping et al. |
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| Affiliation: | GAO Li-jun,QI Xiao-yong,WANG Xiu-ping,et al.Heart Center,Hebei General Hospital,Shijiazhuang 050051,China |
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| Abstract: | Objective To study the influences of rosuvastatin on lipid level and thickness of plaque in patients with carotid atherosclerosis and to observe its long-term effects on atherosclerosis.Methods 40 patients diagnosed by Color Doppler ultrasound with carotid artery plaque from clinics and medical centers from January 2008 to December 2009 were randomly divided into treatment group and control group,with each group 20 cases.The treatment group was given rosuvastatin 10 mg/d combined with enteric-coated aspirin... |
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| Keywords: | Rosuvastatin Atherosclerosis plaque Carotid stenosis |
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