| 唑来磷酸联合卡培他滨治疗乳腺癌多发骨转移临床疗效研究 |
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| 引用本文： | 张明帅,张国庆,欧江华,艾司克尔·阿尤甫,蒋威华,倪多. 唑来磷酸联合卡培他滨治疗乳腺癌多发骨转移临床疗效研究[J]. 中国全科医学, 2011, 14(35) |
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| 作者姓名： | 张明帅 张国庆 欧江华 艾司克尔·阿尤甫 蒋威华 倪多 |
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| 作者单位： | 新疆医科大学附属肿瘤医院乳腺外科,新疆乌鲁木齐市,830011 |
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| 摘 要： | 目的探讨唑来磷酸联合卡培他滨治疗乳腺癌多发骨转移的效果及安全性。方法将48例乳腺癌骨转移患者随机分为唑来磷酸联合卡培他滨组(治疗组)及单用唑来磷酸组(对照组),分别对两组进行镇痛效果、生存质量改善评价、骨转移灶治疗效果评价及观察不良反应。结果两组患者治疗后骨痛的镇痛效果评价、患者生存质量改善评价,差异均无统计学意义(P>0.05);两组骨转移灶治疗效果评价,差异有统计学意义(P<0.05);两组患者的乏力、发热、恶心、呕吐、腹泻发生率比较,差异均无统计学意义(P>0.05)。结论唑来磷酸联合卡培他滨对乳腺癌骨多发转移较单用唑来磷酸有较好的治疗效果。
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| 关 键 词： | 乳腺肿瘤 骨转移 唑来磷酸 卡培他滨 |
Clinical Efficacy Research on Zoledronic Acid Combined with Capecitabine in Treating Breast Cancer with Multiple Bone Metastases |
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| ZHANG Ming-shuai,ZHANG Guo-qing,OU Jiang-hua,et al.. Clinical Efficacy Research on Zoledronic Acid Combined with Capecitabine in Treating Breast Cancer with Multiple Bone Metastases[J]. Chinese General Practice, 2011, 14(35) |
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| Authors: | ZHANG Ming-shuai ZHANG Guo-qing OU Jiang-hua et al. |
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| Affiliation: | ZHANG Ming-shuai,ZHANG Guo-qing,OU Jiang-hua,et al.Department of Breast Surgery,Affiliated Tumor Hospital,Xinjiang Medical University,Urumq 830011,China |
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| Abstract: | Objective To investigate the efficacy and safety of zoledronic acid combined with capecitabine in treating breast cancer patients with multiple bone metastases.Methods 48 breast cancer patients with multiple bone metastases were randomly divided into two groups:group zoledronic acid plus capecitabine(treatment group)and group zoledronic acid alone(control group).Analgesic effect,quality of life improvement,effect of the treatment for bone metastases and toxicity were compared between two groups.Results Ther... |
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| Keywords: | Breast neoplasms Bone metastases Zoledronic acid Capecitabine |
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