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| 甲地孕酮对晚期直肠癌患者化疗期间及化疗后生活质量的影响研究 | |
| 引用本文： | 艾力江·吐尔逊,帕丽达·阿皮孜,张莉,张建清,杨媚. 甲地孕酮对晚期直肠癌患者化疗期间及化疗后生活质量的影响研究[J]. 中国全科医学, 2011, 14(36) |
| 作者姓名： | 艾力江·吐尔逊 帕丽达·阿皮孜 张莉 张建清 杨媚 |
| 作者单位： | 1. 新疆医科大学第一附属医院肿瘤中心,新疆乌鲁木齐市,830011 2. 新疆医科大学附属肿瘤医院胸腹放疗科 |
| 基金项目： | 国家自然科学基金(30760239); 新疆维吾尔自治区自然科学基金(2010211A47) |
| 摘 要： | 目的探讨甲地孕酮(MPA)在肿瘤化疗期间及化疗后对改善晚期直肠癌患者生活质量的作用。方法搜集新疆医科大学第一附属医院2007年6月—2010年2月收治的143例晚期直肠癌患者,将其随机分为单纯化疗(对照组)及化疗联合MPA(试验组),观察治疗期间及化疗后食欲、食量、体质量变化,化疗毒副作用及全身情况变化。结果试验组47例(64.4%)进食量增加,42例(57.5%)体质量增加;对照组10例(14.3%)进食量增加,6例(8.6%)体质量增加,两组比较差异均有统计学意义(P=0.0001)。试验组53例(72.6%)体力状况(KPS)评分改善,对照组13例(18.6%)KPS评分改善,两组比较差异有统计学意义(P=0.0001)。两组腹泻发生率比较差异无统计学意义(P=0.304),而试验组恶心、呕吐的发生率尤其是Ⅲ～Ⅳ度恶心、呕吐的发生率较对照组均明显减轻,差异有统计学意义(P<0.05)。两组血红蛋白下降,发生Ⅲ～Ⅳ度贫血及平均恢复时间,白细胞计数下降,发生Ⅲ～Ⅳ度白细胞计数下降及平均恢复时间比较差异均有统计学意义(P<0.05)。两组血小板计数下降,发生Ⅲ～Ⅳ度血小板计数下降及平均恢复时间比较差异无统计学... |
| 关 键 词： | 直肠肿瘤 抗肿瘤联合化疗方案 甲地孕酮 生活质量 |
The Effect of Megestrol Acetate on Life Quality of Patients with Advanced Rectal Cancer during Chemotherapy |
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| Alijiang terxun,Plida apzi,ZHANG Li,et al.. The Effect of Megestrol Acetate on Life Quality of Patients with Advanced Rectal Cancer during Chemotherapy[J]. Chinese General Practice, 2011, 14(36) | |
| Authors: | Alijiang terxun Plida apzi ZHANG Li et al. |
| Affiliation: | Alijiang terxun,Plida apzi,ZHANG Li,et al.Tumor Center,the First Affiliated Hospital of Xinjiang Medical University,Wrumqi 830011,China |
| Abstract: | Objective To observe the assisting effect of megestrol acetate on improving life quality of the patients suffering from advanced rectal cancer during Chemotherapy.Methods 143 cases sufferring from advanced rectal cancer admitted to the first affiliated hospital of Xin Jiang Medical University from June 2007 to December 2010 were cellected,and they were divided into control group treated only by chemotherapy and experiment group treated by chemotherapy combined with MPA.Appetite,weight,toxicum reaction and t... |
| Keywords: | Rectal neoplasms Antineoplastic combined chemotherapy protocols Megestrol Quality of life |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |