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ROLE of exercise in maintaining the integrity of the neuromuscular junction
Authors:Hiroshi Nishimune PhD  John A. Stanford PhD  Yasuo Mori PhD
Affiliation:1. Department of Anatomy and Cell Biology, University of Kansas School of Medicine, , Kansas City, Kansas, 66160 USA;2. Department of Molecular and Integrative Physiology, University of Kansas School of Medicine, , Kansas City, Kansas, USA;3. Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, , Katsura, Kyoto, Japan
Abstract:
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin‐1, peroxisome proliferator–activated receptor gamma coactivator 1α, insulin‐like growth factor‐1, glial cell line–derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age‐dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49 :315–324, 2014
Keywords:active zone  aging  exercise  laminin  synapse
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