辛伐他汀对高血压患者血管内皮功能的影响

目的观察辛伐他汀对高血压患者血管内皮功能的影响。方法将89例高血压患者随机分为2组:治疗组予辛伐他汀40 mg 1次/d口服,对照组给予常规治疗。12周后观察2组血脂、血浆内皮素(ET)、血清一氧化氮(NO)水平的变化,并观察用药前后颈动脉内-中膜厚度(IMT)及肱动脉内皮依赖性舒张功能(FMD)和硝酸甘油介导的肱动脉内皮非依赖性舒张功能(NMD)的变化。结果治疗前后比较,治疗组血浆ET水平明显下降(P<0.01),NO水平明显升高(P<0.01),IMT及FMD明显改善(P<0.05,P<0.01)。对照组上述指标均无明显改善(P均>0.05)。结论辛伐他汀可以改善高血压患者血管内皮功能。

Effect of simvastatin on vascular endothelium function in patients with hypertension

Objective It is to observe the effect of simvastatin on vascular endothelium function in patients with hypertension.Methods 89 patients with hypertension were divided into 2 groups randomly: treatment group was given simvastatin 40mg once a day by oral use and control group was treated with normal methods.Level changes of blood lipids,plasma ET and NO were observed in 12 weeks later.The thickness of the intima-media(IMT) of the carotid wall,endothelial dependent dilation(flow-mediated dilation,FMD) in brachial artery,endothelium-independent dilation(nitroglycerin-mediated dilation,NMD)were observed before and after treatment.Results Compared with that beforer treatment,plasma ET was significantly reduced(P<0.01) and NO was significantly increased(P<0.01)after treatment.IMT and FMD were improved significantly(P<0.05 and P<0.01).The indexes above were not improved obviously in the control group(P>0.05).Conclusion Simvastatin can improve vascular endothelium function in patients with hypertension.