| 基于代谢组学的小儿腺病毒肺炎痰热闭肺证生物标志物研究思路 |
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| 引用本文： | 王昕泰,杜丽娜,汪受传.基于代谢组学的小儿腺病毒肺炎痰热闭肺证生物标志物研究思路[J].世界科学技术-中医药现代化,2015,17(10):2177-2180. |
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| 作者姓名： | 王昕泰 杜丽娜 汪受传 |
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| 作者单位： | 南京中医药大学中医儿科学研究所 南京 210023；江苏省儿童呼吸疾病（中医药）重点实验室 南京 210023,南京中医药大学中医儿科学研究所 南京 210023；江苏省儿童呼吸疾病（中医药）重点实验室 南京 210023,南京中医药大学中医儿科学研究所 南京 210023；江苏省儿童呼吸疾病（中医药）重点实验室 南京 210023 |
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| 基金项目： | 国家自然科学基金委面上项目（81373688）：基于代谢组学的小儿病毒性肺炎证候学生物标记物研究，负责人：汪受传；国家重点南京中医药大学中医医史文献学科开放课题（WX2013-03）：汪受传教授治疗小儿咳嗽医案要素数据挖掘分析，负责人：王昕泰、仇云龙。 |
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| 摘 要： | 中医证候的科学实质研究是中医现代化的关键，本文尝试阐述一种中医证候基础研究的初步思路，即通过考查现有的小儿腺病毒肺炎及其中医药治疗现状、代谢组学及其在中医证候的应用现状，探讨
其在小儿病毒性肺炎诊疗规范中的应用价值。该方法主要通过能体现中医学“整体观念”的代谢组学作为技术手段，研究小儿病毒性肺炎中最常见的痰热闭肺证；并通过与健康儿童的代谢物质进行比较，确认小儿病毒性肺炎之痰热闭肺证的生物标志物。
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| 关 键 词： | 腺病毒肺炎 痰热闭肺 证候 代谢组学 生物标志物 |
| 收稿时间： | 2015/5/27 0:00:00 |
| 修稿时间： | 2015/7/15 0:00:00 |
New Research Ideas on Biomarkers of Syndrome of Phlegm-heat Obstructing the Lung in Children with Adenovirus Pneumonia |
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| Wang Xintai,Du Lina and Wang Shouchuan.New Research Ideas on Biomarkers of Syndrome of Phlegm-heat Obstructing the Lung in Children with Adenovirus Pneumonia[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2015,17(10):2177-2180. |
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| Authors: | Wang Xintai Du Lina and Wang Shouchuan |
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| Institution: | Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, China; Jiangsu Key Laboratory of Pediatric Respiratory Disease (Traditional Chinese Medicine), Nanjing 210023, China |
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| Abstract: | Study on the scientific essence of traditional Chinese medicine (TCM) syndrome is the key in TCM modernization. This paper showed new research ideas for TCM syndrome, which was based on the pediatric adenovirus pneumonia and its TCM treatment, metabonomics and its application in TCM syndrome research, in order to discuss its application value in the diagnosis and treatment of pediatric viral pneumonia. This method was mainly implemented through the metabonomics technology, which reflected TCM holism concept. The syndrome of phlegm-heat obstructing the lung, which was the most frequent syndrome in the pediatric viral pneumonia, was
studied. Through the comparison with metabolites of healthy children, the biomarkers of syndrome of phlegmheat obstructing the lung in pediatric viral pneumonia were identified. |
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| Keywords: | Adenovirus pneumonia syndrome of phlegm-heat obstructing the lung traditional Chinese medicine syndrome metabonomics biomarkers |
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