琥珀酰明胶与羟乙基淀粉血液稀释对患者血清电解质和血浆组胺的影响

目的 观察4%琥珀酰明胶和6%羟乙基淀粉13010.4行急性高容血液稀释对患者血清电解质及血浆组胺的影响.方法 选择食管癌、结肠癌择期手术60例,随机分为G、H两组(n=30).G组输注4%琥珀酰明胶15ml/kg;H组输注6%羟乙基淀粉130/0.4 15 ml/kg.两组患者麻醉诱导后10 min开始行急性高容量血液稀释(acute hypervolemic hemodilution,AHH),分别在AHH前(To)、开始AHH后5 min(T1)、开始AHH后30 min(T2)、完成AHH后30 min(T3)、完成AHH后1h(T4)、完成AHH后3 h(T5)分别采集静脉血,检测静脉血检测Hct和血清电解质Na+、K+、Ca2+,Cl+的变化及血浆组胺的变化.结果 血清电解质的变化:组间比较,Na+、K+、ca2+、Cl-值在各时间点两组间比较无统计学差异;组内比较:G、H两组Na+、Cl-、K+、Ca2+值在T1～L时间点与To时间点比较有统计学差异(P

Effects of succinylated gelatin and 6%HES130/0.4 hemodilution on serum electrolytes and plasma histamine

Objective To investigate the effects of acute hypervolemic hemodilution(AHH)using 4% succomuylated gelatin and hvdmxvethvl starch on serum electrolyte and plasma histamine.Methods Sixty patients suffered from esophageal carcino-ma or colon carcinoma were randomized into 2 groups(n=30)receiving intravenously 15 ml/kg of succinylated gelatm(group G)or 6% HES 130/0.4(group H).AHH was conducted 10 min after anesthesia induction-Levels of Hot,serum electrolyte and plasma histamine were measured before AHH,5 min(T1),30 min(T2)of AHH,30 min(T3),1h(T4)and 3 h after AHH termination,respectively,AHH(T3).Results The levels of serum Na+,K+,Ca2+.Cl- and plasma histsmine at T1,T2,T3 and T4 were significantly lower and higher respectively than those at To,with no statistical difference between two groups at each same time-point.Conclusion AHH using succinylated gelatin or hydroxyethyl starch is safe although bringing slight change in serum electrolytes and plasma histamine levels.