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| 荧光原位杂交检测乳腺癌HER2基因的表达及其意义 | |
| 引用本文： | 刘彦恒,赫银再,韩秀花,张帆,宋晓燕,李军华,李英彬,关宁虎. 荧光原位杂交检测乳腺癌HER2基因的表达及其意义[J]. 内蒙古医学杂志, 2010, 42(1): 1-4,F0004 |
| 作者姓名： | 刘彦恒 赫银再 韩秀花 张帆 宋晓燕 李军华 李英彬 关宁虎 |
| 作者单位： | 内蒙古自治区医院肿瘤科、病理科,内蒙古,呼和浩特,010017 |
| 基金项目： | 卫生部科研基金项目(WKJ20073001) |
| 摘 要： | 目的：探讨荧光原位杂交（FISH）在检测乳腺癌组织HER2基因表达的临床意义。方法：应用FISH法对50例乳腺癌患者进行HER2基因检测,分析基因表达程度与临床特征之间的关系,比较基因和免疫组化（IHC）法蛋白表达的差异性。结果：FISH法与IHC法检测结果总符合率为88%,我院女性乳腺癌人群中HER2基因过表达率为44%,其过表达与肿瘤大小、淋巴结转移、临床分期之间差异无统计学意义（P〉0.05） 孕激素受体（PR）阳性组高于PR阴性组,差异有统计学意义（P〈0.01） 雌激素受体（ER）阳性组与ER阴性组间差异无统计学意义（P〉0.05）。结论：HER2基因的过表达与肿瘤大小、淋巴结转移、临床分期及ER无关,与PR成负相关。FISH法检测乳腺癌HER2基因敏感性及稳定性较高,可作为最终确诊HER2基因状态的方法。 |
| 关 键 词： | 乳腺癌 HER2基因 免疫组化 荧光原位杂交 |
The Significance and Expression of HER2 Gene by Fluorescence in Situ Hybridization in Breast Cancer |
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| LIU Yan-heng,HE Yin-zai,HAN Xiu-hua,ZHANG Fan,SONG Xiao-yan,LI Jun-hua,LI Ying-bin,GUAN Ning-hu. The Significance and Expression of HER2 Gene by Fluorescence in Situ Hybridization in Breast Cancer[J]. Inner Mongolia Medical Journal, 2010, 42(1): 1-4,F0004 | |
| Authors: | LIU Yan-heng HE Yin-zai HAN Xiu-hua ZHANG Fan SONG Xiao-yan LI Jun-hua LI Ying-bin GUAN Ning-hu |
| Affiliation: | LIU Yan-heng,HE Yin-zai,HAN Xiu-hua,ZHANG Fan,SONG Xiao-yan,LI Jun-hua,LI Ying-bin,GUAN Ning-hu |
| Abstract: | Objective:To explore the clinical implications of the expression of HER2 gene by fluorescence in situ hybridization(FISH) in breast cancer.Methods:HER2 gene in 50 cases with female breast cancer was detected by FISH,and the relationship between HER2 gene over-expression and clinical characters was investigated,and the difference by FISH and immunohistochemistry(IHC) was compared.Results:The total coincident rate by FISH and IHC was 88%,HER2 gene over-expression rate was 44% in female breast cancer of our ho... |
| Keywords: | Breast cancer HER2 gene Immunohistochemistry Fluorescent in situ hybridization |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |