粉防己碱对实验性心肌缺血再灌注损伤影响的研究

为探讨粉防己碱（Tet）对心肌缺血再灌注损伤的影响，将16只杂种犬制作动物模型随机分为用药组和对照组，观察两组白细胞介素－1（IL－1）、肿瘤坏死因子（TNF）、血小板激活因子（PAF）、心肌内髓过氧化物酶（MPO）活性、心肌梗死范围（MIS）等指标。结果表明：用药组MIS较对照组明显缩小，同时IL－1、TNF、PAF、MPO等炎性指标也较对照组明显为低，IL－1、TNF、PAF与MIS存在明显复相关关系，心肌MPO与MIS呈密切正相关。提示Tet具有抗心肌缺血再灌注损伤作用，其机理可能与其抗炎作用有关。

Influence of Tetrandrine on myocardium injury indogs with experimental ischemia reperfusion

To investigate the influence of Tetrandrine (Tet) in treating myocardial ischemia reperfusion injnry, 16 dogs models were divided randomly into Tet group and control group. The changes of interleukin-1 (IL-1), tumor necrosis factor (TNF), platelet activating factor (PAF),endocardiac myeloperoxidase (MPO) and myocardial infarction size (MlS) were observed in the 2groups. The results showed:MIS in Tet group was obviously small than that in control group,likewise IL-1,TNF,PAF and MPO in Tet group were obviously lower than that in control group. MIS or MPO was found to have a close coefficient of multiple correlation with the three inflammatony factors (IL-1,TNF,PAF),and between MPO and MIS there was a close positive correlation. The results indicated that Tet played an important role in protecting reperfusion of ischemic myocardium,this mechanism might relate to anti-inflammatory function of Tet.