| 伊曲康唑影响的药代动力学相互作用研究进展 |
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| 引用本文： | 苗彩云,陈漪,陈江飞. 伊曲康唑影响的药代动力学相互作用研究进展[J]. 中国临床药理学与治疗学, 2009, 14(10): 1183-1192 |
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| 作者姓名： | 苗彩云 陈漪 陈江飞 |
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| 作者单位： | 1. 宁波市妇女儿童医院药剂科,宁波,315012,浙江
2. 宁波市第一医院药剂科,宁波,315010,浙江 |
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| 摘 要： | 伊曲康唑为三唑类广谱抗真菌药,临床应用广泛,具有CYP3A4和P-糖蛋白抑制作用。由于临床CYP3A4和P-糖蛋白底物广泛,它们在口服药物吸收的主要部位胃肠道均有高表达,同时两者的底物具有显著的重叠性,由此导致的受伊曲康唑影响的药代动力学相互作用广泛产生,甚至引起显著的临床意义。本文综述并讨论了受其影响的药代动力学相互作用研究,以促进临床的安全用药。
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| 关 键 词： | 伊曲康唑 抗真菌药 药代动力学 药物相互作用 |
Progress and research in the effect of itraconazole on pharmacokinetic drug-drug interactions |
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| MIAO Cai-yun,CHEN Yi,CHEN Jiang-fei. Progress and research in the effect of itraconazole on pharmacokinetic drug-drug interactions[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1183-1192 |
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| Authors: | MIAO Cai-yun CHEN Yi CHEN Jiang-fei |
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| Affiliation: | 1Department of Pharmacy, Ningbo Women and Children ＇ s Hospital, Ningbo 315012, Zhejiang , China ; 2Department of Pharmacy, Ningbo NO. 1 Hospital, Ningbo 315010, Zhejiang, China) |
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| Abstract: | Itraconazole,as one of the broad-spectrum antifungal drags,is an inhibitor of CYP3A4 and P-glycoprotein and was widely used in clinic.CYP3A4 and P-glycoprotein with extensive substrate have present at high levels in gastrointestinal tract,the primary site of absorption for orally administrated drugs,and share a significant overlap in substrate specificity,thus resuhing in widely phannaeokinetie interaction by itraconazole,part of which has clinical importance.In this article,the effect of itraconazole on phannaeokinetie drug-drug interactions is reviewed and discussed in order to promote its safe usage. |
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| Keywords: | itraconazole antifugal drug pharmacokinetics drug-drug interaction |
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