| 不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量 |
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| 引用本文： | 刘海涛,王俊秋,余立. 不同溶出介质的多条溶出曲线评价盐酸普萘洛尔片内在质量[J]. 中国药业, 2012, 21(7): 15-16 |
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| 作者姓名： | 刘海涛 王俊秋 余立 |
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| 作者单位： | 北京市药品检验所,北京,100032 |
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| 摘 要： | 目的 测定21个厂家生产的盐酸普萘洛尔片在不同溶出介质中的溶出度,通过溶出曲线来评价药品内在质量.方法 在4种溶出介质中,采用桨法进行溶出度试验,使用不同介质中的溶出曲线对结果进行分析和比较.结果 与结论各厂家产品溶出行为差别较大,产品质量存在差异.
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| 关 键 词： | 盐酸普萘洛尔片 溶出度 溶出曲线 紫外分光光度法 |
Evaluation of Quality of Propranolol Hydrochloride Tablets by Dissolution Curves in Different Mediums |
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| Liu Haitao , Wang Junqiu , Yu Li. Evaluation of Quality of Propranolol Hydrochloride Tablets by Dissolution Curves in Different Mediums[J]. China Pharmaceuticals, 2012, 21(7): 15-16 |
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| Authors: | Liu Haitao Wang Junqiu Yu Li |
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| Affiliation: | ( Beijing Institute for Drug Control, Beijing, China 100032) |
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| Abstract: | Objective To detect the dissolution of propranolol hydrochloride tablets from different pharmaceutical factories in 4 different mediums and evaluate the quality by dissolution curves. Methods The dissolution test was carried out with paddle- rotating method. To analyse and compare the results by the dissolution curves in different mediums. Results and Conclusion There was significant dif- ference in dissolution parameters and the quality among the propranolol hydrochloride tablets preparations from different manufactories. |
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| Keywords: | Propranolol Hydroehloride Tablets dissolution Weibull Equation UV - spectrophotometry |
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