文拉法辛和氟西汀治疗抑郁症患者的比较研究

目的 比较文拉法辛和氟西汀两种药物治疗抑郁症的疗效与安全性.方法 将符合<中国精神障碍分类与诊断标准(第三版)>(CCMD-3)抑郁症诊断标准的110例患者随机分为2组,文拉法辛组(n=30)和氟西汀组(n=80),疗效采用汉密尔顿抑郁量表(HAMD)评定,治疗中出现的安全性和不良反应由副反应量表(TESS)评定.结果 文拉法辛组治疗后总显效率为76.67%,总有效率为93.33%;氟西汀组治疗后总显效率为65.00%,总有效率为88.75%.两组比较,差异无统计学意义(P>0.05).结论 文拉法辛治疗抑郁症患者安全有效,不良反应与氟西汀无显著差异,疗效相似.

Comparative Study on Venlafaxine and Fluoxetine in Treatment of Patients with Depression

Objective To comparatively study the efficacy and safety of venlafaxine and fluoxetine in the treatment of the patients with depression. Methods According to the Category and Diagnostic Criteria of Mental Disorder of China, third edition（CCMD-3）, 110 cases of depression were randomly divided into two groups, venlafaxine group （n =30） and the fluoxetine group （n = 80）. The efficacy was assessed using the Hamilton Depression Scale （HAMD）. The safety and adverse reactions were assessed by the Treatment Emergent Symptom Scale（TESS）. Results The excellent effective rate and the effective rate were 76.67% and 93.33% in the venlafaxine group, and 65.00% and 88.75% in the fluoxetine group without statistical difference between them（P〉 0.05）. Conclusion Venlafaxine is safe and effective to treat depression, the adverse reactions and the curative efficacy have no significant difference with fluoxetine.