肿瘤标志物的联合检测在肺癌诊断中的临床价值 |
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引用本文: | 李莹,陈玲玲,姜浩,冯军.肿瘤标志物的联合检测在肺癌诊断中的临床价值[J].中国误诊学杂志,2012,12(18):4869-4871. |
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作者姓名: | 李莹 陈玲玲 姜浩 冯军 |
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作者单位: | 河北省承德市中心医院检验科,067000 |
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摘 要: | 目的探讨血清中CEA、CA125、NSE和CYFRA21-1四种肿瘤标志物联合检测在不同组织类型肺癌中的临床诊断价值。方法采用电化学发光免疫分析技术测定116例肺癌患者及65例健康人血清中的CEA、CA125、NSE利CYFRA21-1水平。结果CYFRA21-1、NSE、CEA、CA125四项肿瘤标志物肺癌组检测水平均显著高于对照组(P〈0.01),肿瘤标志物测定水平与病理组织类型有关。其中CYFRA21-1在鳞癌及腺癌的阳性率分别为73.21%、63.64%;NSE在小细胞肺癌的阳性率为62.50%;CEA和CA125检测的阳性率及血清水平以腺癌最高;四项联合检测的阳性率为82.76%。结论血清CEA、CA125、NSE和CYFRA21-1的联合检测有助于提高肺癌的诊断效率,并对组织分型有较高的参考价值。
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关 键 词: | 肺肿瘤/代谢 癌胚抗原/血液 CA-125抗原/血液 磷酸丙酮酸水合酶/血液 抗原,肿瘤/血液 角蛋白质类/血液 |
Diagnostic value of combined detection of serum tumor markers in patients with lung cancer |
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Institution: | LI Ying, CHEN Ling-ling, j IANG Hao, FENG J un Department of Laboratory, Center Hospital of Chengde , Chengde 067000, China |
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Abstract: | Objective To investigate the clinical value of combined measurement of serum CEA, CA125, NSE, CY- FRA21-1 for the diagnosis of lung cancer. Methods One hundred and sixteen patients with lung cancer confirmed histologically were studied. The levels of CEA, CA125 CYFRA21-1, NSE were assayed and compared between the lung cancer group( 116 cases) and healthy control group(65 cases) by electrochemiluminesence immunoassay. Results The levels of CYFRA21-1, NSE,CEA, and CA125 in the lung cancer group were significantly higher than those in the control group(P〈0.01). The levels of serum CEA,CA125, CYFRA 21-1 and NSE were related to types of pa- thology. The highest positive rates of CYFRA 21-1 for squamous cell carcinoma were 73.21% and 63.64% for ade- nocarcinoma;Tbe positivity of NSE for small cell lung cancer (SCLC) was 62.50% ;The higher levels and positivity of CEA and CA125 appeared in adenocareinoma. Their combined detection could markedly improve the positivity for lung cancer detection (82.76%). Conclusion CEA,CA125 ,CYFRA21-1 and NSE are useful for the diagnosis of the lung cancer and histological type, especially combining detection of the four serum tumor markers . |
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Keywords: | Lung Neoplasms/metabolism Carcinoembryonic Antigen/Blood CA-125 Antigen/Blood Phosphopyruvate Hydratase/Blood Antigens Neoplasm/Blood Keratins/Blood |
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