| 大分子为载体的抗体偶联药物研究进展 |
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| 引用本文： | 覃素华,潘君,张兵兵.大分子为载体的抗体偶联药物研究进展[J].中国新药杂志,2004,13(6):488-491. |
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| 作者姓名： | 覃素华 潘君 张兵兵 |
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| 作者单位： | 重庆大学生物工程学院,教育部生物力学与组织工程重点实验室,重庆,400044 |
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| 摘 要： | 抗体偶联药物与肿瘤相关靶点结合有特异性,对肿瘤细胞有选择性杀伤作用,临床上已开始用于治疗肿瘤.综述了抗体与抗癌药物偶联物的偶联方式和药物释放的靶向机制,以及采用大分子聚合物做载体(如葡聚糖、人血清白蛋白、聚N-2羟丙甲基丙烯酰胺)的抗体偶联药物的研究现状.
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| 关 键 词： | 抗体 免疫偶联物 抗癌药物 大分子 |
| 文章编号： | 1003-3734(2004)06-0488-04 |
Advances in research antibody-immunoconjugated agents using macromolecule as carrier |
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| QIN Su-hua,PAN Jun,ZHANG Bing-bing.Advances in research antibody-immunoconjugated agents using macromolecule as carrier[J].Chinese Journal of New Drugs,2004,13(6):488-491. |
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| Authors: | QIN Su-hua PAN Jun ZHANG Bing-bing |
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| Abstract: | Antibody-immunoconjugated agents show specific binding property to tumor related targets and exhibit selective cytotoxicity to target cancer cells. Now, some of these agents have been used in clinical therapy. In this paper, the conjugated patterns and the mechanism for targeting release as well as research advances in using macromolecule as carrier in these drugs were reviewed. |
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| Keywords: | antibody immunoconjugates anti-cancer drugs macromolecules |
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