单肺通气中右美托咪定辅助麻醉对肺通气/血流的影响

目的：观察在单肺通气中，右美托咪定辅助麻醉血流动力学，是否有助于改善单肺通气时的肺通气/血流异常。方法单肺通气下食管癌根治术60例，分为对照组和实验组。对照组麻醉诱导后注射0.9%生理盐水10 mL，实验组麻醉诱导后右美托咪定0.6μg/kg（10 min输入）。观察两组术中单肺通气时间、手术时间、气道分压、氧分压；观察术前、插管前、插管后、插管后15 min、切皮时、进胸、单肺通气60 min、单肺通气90 min、双肺通气15 min时间点的平均动脉压（MAP）、心率（HR）；观察术前、单肺通气60 min、单肺通气90 min时间点的氧和指数。结果本研究结果显示氧和指数在术前时间点，实验组与对照组比较差异无统计学意义（P>0.05）；氧和指数在单肺通气60 min、单肺通气90 min时间点，实验组与对照组比较差异有统计学意义（P<0.05），其机制可能就是减轻了单肺通气引起急性肺损伤。 HR、MAP在插管前、插管后、插管后15 min、切皮时、进胸、单肺通气60 min、单肺通气90 min、双肺通气15 min时间点，实验组与对照组比较差异有统计学意义（P<0.05）。结论在单肺通气中，右美托咪定辅助麻醉血流动力学更平稳，氧和指数增加，有助于改善单肺通气时的肺通气/血流异常。

Single Lung Ventilation of Dexmedetomidine Assisted Anesthesia on Pulmonary Ventilation/Blood Flow

Objective Observed in single lung ventilation,right the microphones on auxiliary anesthesia hemodynamic, whether to help to improve the single lung ventilation lung ventilation/blood flow abnormalities.Methods 60 cases of esophageal cancer radical under one-lung ventilation were divided into control group and experimental group.Control group 0.9% saline injec-tion 10 mL after anesthesia induction,the experimental group after anesthesia induction right set beauty holds the mi 0.6 mu g/kg (input) 10 minutes.Observe two groups of related indicators: single lung ventilation time,operation time,airway pressure,oxygen partial pressure;Observe preoperative,15 minutes before intubation and after intubation and after intubation,cut skin,into the chest,single lung ventilation when 60 minutes,90 minutes of single lung ventilation,double lung ventilation 15 minutes time point of the mean arterial pressure (MAP),heart rate (HR);Observe preoperatively,single lung ventilation 60 minutes,90 minutes of one-lung ventilation and oxygen index.Results This study results show that the oxygen and index in preoperative point in time,the ex-perimental group there was no statistically significant difference compared with control group (P>0.05);Oxygen index and one-lung ventilation 60 minutes,single lung ventilation in 90 minutes,the experimental group compared with control group difference was sta-tistically significant(P<0.05),its mechanism is probably reduced the single lung ventilation cause acute lung injury.HR,MAP before intubation and after intubation,15 minutes after intubation,cutting leather,into the chest,single lung ventilation when 60 minutes, 90 minutes of single lung ventilation,double lung ventilation 15 minutes time,the experimental group compared with control group difference was statistically significant (P<0.05).Conclusion In single lung ventilation,right the mi auxiliary anesthesia hemody-namic more smoothly,and oxygen index increased,contribute to the improvement of the lung ventilation of single lung ventilation/abnormal blood flow.