失代偿肝硬化患者院内感染的临床特点分析

目的总结失代偿肝硬化患者发生院内感染的临床特点,为减少院内感染的发生提供经验。方法分析2006年1月至2010年11月期间,596人次失代偿期肝硬化住院患者发生院内感染的情况,包括院内感染率、各种原因肝硬化院内感染率、院内感染发生部位、感染诱因及预后。结果在596人次的失代偿期肝硬化患者中,发生院内感染94人次,发生率为15.77%。其中,男性55人次,女性39人次。Child-Pugh C级的为77人次(81.91%),B级17人次(18.09%)。上消化道出血后发生院内感染为21人次(22.34%)。最常见的感染部位为上呼吸道和肺部,其次为消化道和腹腔。发生院内感染的患者中,10人在发生院内感染后死亡。结论失代偿肝硬化患者易发生院内感染,特别是Child-Pugh C级的患者,消化道出血为较常见的诱因,对此类患者应特别关注。

Clinical features of hospital-acquired infections in decompensate cirrhosis

Objective Clinical features of hospital - acquired infections in decompensate cirrhosis were analyzed to improve the diagnostic level of the disease. Methods Five hundred and ninety - six cases with hospital - acquired infections in decompensate cirrhosis admitted to the hospital from Jan, 2006 to Nov, 2010 were retrospectively reviewed including the rate, sites, causes and prognosis of infections. Results Ninety - four infections were observed among 596 patients （ 15.77%, male 55 patients, female 39 patients）, hospital - acquired infections were more frequent among patients with Child -Pugh C than Child -Pugh B （81.91% vs 18.09% ）. Infectious occurred more frequently in patients after gastrointestinal bleeding （22.34%）. The most frequent infective sites include respiratory infections, infection of gastrointestinal tract and spontaneous bacterial peritonitis. Ten patients were died after hospital - acquired infections. Conclusion Hospital - acquired infection is a frequent and severe complication in decompensate cirrhotic patients, especially in patients with Child - Pugh C grading and gastrointestinal bleeding.