| 奥氮平与氯氮平治疗精神分裂症的比较研究 |
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| 引用本文： | 邓河晃,郑洪波,何柱国,周亮.奥氮平与氯氮平治疗精神分裂症的比较研究[J].上海精神医学,2000,12(3):143-145. |
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| 作者姓名： | 邓河晃 郑洪波 何柱国 周亮 |
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| 作者单位： | 510370,广州市精神病医院 |
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| 摘 要： | 目的：评价奥氮平治疗精神分裂症的临床疗效与安全性，方法 ８０例精神分裂症患者随机分成２组，分别给予奥氮平与氯氮平治疗１２周，采用ＰＡＮＳＳ评价临床疗效，ＴＥＳＳ评价不良反应。结果：全部病人完成疗程，奥氮平组治疗前后ＰＡＮＳＳ减分率４２．４％，有效率为８２．５％，氯氮平组治疗前后ＰＡＮＳＳ减分率３７．５％，有效率为７０％，未见严重的药物不良反应，安全性好。结论：奥氮平是一种有效的治疗精神分裂症的药物
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| 关 键 词： | 精神分裂症 奥氮平 氯氮平 疗效 |
| 修稿时间： | 2000年6月7日 |
A comparative trial of olanzapine versus clozopine in the treatment of schizophrenia |
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| Deng Hehuang,Zheng Hongbo,He Zhuguo,et al..A comparative trial of olanzapine versus clozopine in the treatment of schizophrenia[J].Shanghai Archives of Psychiatry,2000,12(3):143-145. |
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| Authors: | Deng Hehuang Zheng Hongbo He Zhuguo |
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| Institution: | Deng Hehuang,Zheng Hongbo,He Zhuguo,et al. Guangzhou Psychiatric Hospital,Guangdong 510370 |
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| Abstract: | Objectives: To evaluate the efficacy and safety of olanzapine in the treatment of schizophrenia. Method: Eighty patients with schizophrenia were randomly assigned into the treatment groups of olanzapine or clozapine for 12 weeks. PANSS and TESS scales were used to measure their efficacy and safety. Results: 82. 5% patients responded to olanzapine treatment while 70. 0% responded to clozapine (X2 = 21. 80, p=0. 40) ; The total PANSS scores were decreased by 42. 4% after 12 weeks of olanzapine treatment while there were 37. 5% reduction in clozapine group. A significant difference was found in the profile of side effects between the two groups. Conclusion: Olanzapine is effective in treating schizophrenia. |
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| Keywords: | Schizophrenia Olanzapine Clozapine Efficacy |
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