A型肉毒毒素治疗急性共同性内斜视的小样本效果观察

目的评价A型肉毒毒素（BTXA）治疗小样本的急性共同性内斜视的效果。设计回顾性病例系列。研究对象6例6～34岁急性共同性内斜视患者。方法所有患者在肌电放大仪引导下行双侧内直肌注射BTXA一次，两眼分别为2．5单位，注射前后行三棱镜交替遮盖检查斜视度，同视机及立体视觉检查图检查。主要指标斜视度及立体视功能。结果6例患者随访时间4～39个月。注射前平均内斜视度数为（43．3±1．0）△，最后一次随访时为（3．3±8．2）n，其中5例眼位正位。注射前1例患者具有远立体视，2例患者近立体视为600秒和40秒，注射后5例患者具有远、近立体视（3例40秒，1例60秒，1例200秒）。结论本文有限的资料表明，BTXA是治疗急性共同性内斜视有效的可选择方法。（眼科，2010，19：110-112）

The role of botulinum toxin for acute-onset concomitant esotropia: a pilot study

Objective To observe the effectiveness of botulinum toxin A （BTXA） in the treatment of small sample patients with acute acquired concomitant esotropia. Design Retrospective case series. Participants 6 patients （3 female and 3 male） with acute acquired concomitant esotropia aged 6 to 34 years. Methods All the patients were received 2.5 units of BTXA injected into the bilateral medial rectus muscles once under electromyographic control. They were performed alter prism-cover test, synoptophore and stereoscopic charts test. Main Outcome Measures The alignment of eyes and binocular vision. Results The follow-up of patients was 4 to 39 months. The pre-injection angle of deviation was 43.3±1.0a; the angle of deviation at the last follow-up was 3.3±8.2a, and 5 patients achieved alignment. In pre-injection, one patient had distance stereopsis, 2 patients had near stereopsis with 600 seconds and 40 seconds; after injection, 5 patients demonstrated distance and near stereeopsis （3 patients 40 seconds, 1 patient 60 seconds, and 1 patient 200 seconds）. Conclusion This small sample study shows that BTXA injection is effective alternative in treating acute acquired concomitant esotropia. （Op hthalmol CHN, 2010, 19： 110-112）