可注射吸水膨胀性排龈膏的制备与排龈效果评价

目的研制一种新型可注射、吸水膨胀性排龈材料的膏剂。方法将吸水膨胀性高分子载体基质与高岭土、氯化铝等药物机械混合,获得一种膏剂材料。采用Expasyl R 作为对照,体外评价其在水中的稳定性和吸水膨胀性能,通过动物实验评价其排龈效果。结果新型排龈膏体外吸水膨胀,但是可以维持结构的完整性,不会崩解。动物实验也显示无论在牙龈高度退缩和龈沟宽度变化方面都有良好的排龈效果。结论获得一种新型的具有良好应用前景的可注射吸水膨胀性、遇水不崩解的排龈材料。

Synthesis and evaluation of a novel injectable and water-swelling gingival displacement materials

Objective To synthesize and evaluate a novel injectable and water-swelling gingival displacement mate-rials.Methods A kind of water-swelling polymer,kaolin and aluminum chloride were mechanically mixed at certain ratio in water solution,resulting to a novel paste materials for gingival displacement.Then,its stability in aqueous solution and water swelling properties were evaluated in vitro.The effect on gingival displacement was evaluated by animal experiments in dogs.A commercial gingival displacement materials paste of Expasyl was used as control.Re-sults While contacting with water,the novel gingival displacement paste did not collapse,maintained its integrity structure,and could expand for adsorbing water.Animal experiments in dogs showed that the materials could lead to displace the gingival margins from the dental root surfaces.Conclusion The novel injectable and expanded gingival displacement material is efficient to retract free gingival margin with potential clinical application.