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| 阳和汤干预兔骨关节炎软骨中金属蛋白酶-1及基质金属蛋白酶抑制剂-1变化 | |
| 引用本文： | 陈朝蔚,孙剑,李玉梅,陈永强. 阳和汤干预兔骨关节炎软骨中金属蛋白酶-1及基质金属蛋白酶抑制剂-1变化[J]. 中国中医骨伤科杂志, 2010, 0(8): 1-2 |
| 作者姓名： | 陈朝蔚 孙剑 李玉梅 陈永强 |
| 作者单位： | 上海市中医医院骨伤科; |
| 基金项目： | 上海市基础研究重点项目资助(08JC1418800) |
| 摘 要： | 目的:观察阳和汤对兔骨关节炎软骨中基质金属蛋白酶-1(matrix metalloproteinase-l,MMP-1)及基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloprotease-1,TI MP-1)表达的影响。方法:新西兰大白兔20只随机分为正常组、模型组、氨糖美辛组和阳和汤组。按照Hulth法建立膝骨关节炎模型,术后第5周起至第7周末,阳和汤组予混有阳和汤的颗粒饲料,氨糖美辛组给予混有氨糖美辛的兔饲料,正常组及模型组均给予普通饲料;术后第8周分别取各组胫骨平台关节软骨,采用免疫组织化学染色测定软骨中MMP-1及TI MP-1表达的阳性指数。结果:模型组MMP-1及TI MP-1表达的阳性指数水平明显高于正常组,差异有统计学意义(P0.01),阳和汤组MMP-1及TI MP-1表达阳性指数低于模型组,差异有统计学意义(P0.05)。阳和汤组和氨糖美辛组MMP-1及TI MP-1表达阳性指数比较,差异无统计学意义(P0.05)。结论:阳和汤可能是通过调控软骨细胞外基质中MMP-1及TI MP-1表达变化而维持软骨的动态平衡,延缓骨关节炎中软骨退变。 |
| 关 键 词： | 骨关节炎 阳和汤 软骨 基质金属蛋白酶-1 基质金属蛋白酶抑制剂-1 |
Effects of Yanghe Decoction on matrix metalloproteinase-l and tissue inhibitor of metalloprotease-1 in cartilage of osteoarthritis rabbits |
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| CHEN Chaowei SUN Jian LI Yumei CHEN Yongqiang. Effects of Yanghe Decoction on matrix metalloproteinase-l and tissue inhibitor of metalloprotease-1 in cartilage of osteoarthritis rabbits[J]. Chinese Journal of Traditional Medical Traumatology & Orthopeics, 2010, 0(8): 1-2 | |
| Authors: | CHEN Chaowei SUN Jian LI Yumei CHEN Yongqiang |
| Affiliation: | CHEN Chaowei1 SUN Jian1 LI Yumei1 CHEN Yongqiang11Department of Orthopaedics and Traumatology,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai 200071,China |
| Abstract: | Objective:To observe the effects of Yanghe Decoction on matrix metalloproteinase-l (MMP-1) and tissue inhibitor of metalloprotease-1 (TIMP-1) in cartilage of osteoarthritis rabbits. Methods:Twenty New Zealand white rabbits were randomly divided into normal group,model group,Osaminethacine group and Yanghe Decoction-treated group. The rabbit model of osteoarthritis was established according to Hulth's method. The rabbits were sacrificed at the 8th week after administration of Yanghe Decoction for 14 days,and... |
| Keywords: | Osteoarthritis Yanghe Decoction Cartilage Matrix metalloproteinase-l Tissue inhibitor of metalloprotease-1 |
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