EphA2在涎腺肿瘤中的表达及其临床意义

目的检测EphA2在涎腺肿瘤中的表达，并分析其临床病理意义。方法免疫组化S-P法检测10例正常涎腺组织、30例多形性腺瘤、30例黏液表皮样癌（MEC）、30例腺样囊性癌（ACC）中EphA2的表达。分析EphA2表达与患者的年龄、性别、肿瘤部位、大小、TNM分期以及复发、淋巴结转移等临床病理因素的关系。比较EphA2在正常涎腺组织及几种常见的涎腺良、恶性肿瘤中的表达差异。结果EphA2在正常涎腺组织中主要表达于腺管上皮，而腺泡细胞几乎不表达。EphA2在正常涎腺组织、多形性腺瘤、涎腺癌（包括黏液表皮样癌和腺样囊性癌2组）中的表达依次增高，存在显著性差异（P〈0．05）。EphA2的表达与涎腺癌瘤体大小、TNM分期、复发和淋巴结转移有关（P〈0．05）。结论EphA2可能影响涎腺肿瘤发生、发展及其预后。

Expression and its significance of EphA2 in salivary gland tumors

Objective To evaluate the expression and its clinicopathological significance of EphA2 in normal salivary tissue, benign and malignant salivary tumors. Methods Immunohistochemical staining was used to quantify the protien expression levels of EphA2 in 10 normal salivary tissues, 30 pleomorphic adeonomas, 30 mucoepidermoid carcinomas and 30 adenoid cystic carcinomas. The relationship between the expression of EphA2 and clinicopathologic data was analyzed, including age, sex, location, tumor size, TNM stage, recurrence and lymphatic metastasis. The difffernces of EphA2 expression were compared among normal salivary tissue, pleomorphic adeonoma, mucoepidermoid carcinoma and adenoid cystic carcinoma seperately. Results In all normal salivary tissues ,the EphA2 staining were detected in glandular tube epithelium while EphA2 expression was almost absent in aeinie cells. EphA2 expression increased in turn of normal salivary tissue, pleomorphic adeonoma and salivary carcinoma （including MEC and ACC）, and the differences were significant （P 〈 0.05）. EphA2 expression in salivary carcinomas significantly correlated with tumor size, clinical stage, recurrence and lymphatic metastasis （P 〈 0.05）. Conclusion The results implicated that EphA2 might be related to tumorigenesis, progression and prognosis of salivary tumors.