声触诊组织量化技术在桥本氏甲状腺炎诊断中的应用价值

目的 探讨声触诊组织量化(VTQ)技术在桥本氏甲状腺炎(HT)诊断中的临床应用价值。方法 选取53例HT患者和46例健康志愿者行甲状腺常规超声及VTQ检查，根据剪切波速度绘制ROC曲线。结果 53例HT的二维超声表现分为5类，各类型HT的剪切波速度差异无统计学意义(F=0.424，P=0.790)。ROC曲线分析阈值，当剪切波速度≥2.53时，诊断HT的灵敏度、特异度分别为87 ％、100％。53例HT按甲状腺功能分甲亢、甲减及甲功正常组。三组HT的剪切波速度两两比较，差异无统计学意义(P =0.884)，但均较正常甲状腺组明显增高，差异均有统计学意义(均P=0.000)。结论VTQ技术作为无创、量化检测HT的方法，可评价甲状腺组织的硬度，对HT的诊断有一定帮助。

Initial clinical study of virtual touch tissue quantification on Hashimoto's thyroiditis

Objective To explore the clinical application value of virtual touch tissue quantification (VTQ) technique in Hashimoto's thyroiditis(HT).Methods Fifty-three patients with HT and 46 health subjects were examed by conventional ultrasonography and VTQ, their shear were velocity (Vs) was measured.A receiver-operating characteristie(ROC) curve was drew according to Vs which can obtain the value of optimal operating point for diagnosing HT.Results The 2D ultrasonic appearance of 53 cases HT were classified into five species, but there was no significant difference in the Vs (F = 0.424, P = 0.790).The area under the ROC curve was 0.976,which showed a high statistical significances(P = 0.000).ROC curve displayed that Vs of 2.53 m/s could be used to diagnose HT,the sensitivity and specificity were 87％and 100％ ,respectively.Fifty-three patients with HT were classified into three groups according to thyroid function, 10 patients with hyperthyroidism, 25 patients with hypothyroidism and 18 patients with euthyroidism.The Vs of HT among the three groups were no significant difference(P = 0.884), but their Vs were all obviously higher than that of normal thyroid Vs(P = 0.000).Conclusions VTQ technique can evaluate the hardness of thyroid and has some help for differential diagnosis of HT.