| 乳腺癌端粒酶活性的研究 |
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| 引用本文： | 杨文涛,许良中,张泰明. 乳腺癌端粒酶活性的研究[J]. 中华肿瘤杂志, 1999, 21(4): 278-280 |
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| 作者姓名： | 杨文涛 许良中 张泰明 |
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| 作者单位： | 上海医科大学肿瘤医院分子病理研究室 |
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| 摘 要： | 探讨乳腺癌中端粒酶活性的意义及其与腋窝淋巴结状态的关系。方法用建立在多聚酶链反应基础上的端粒重复序列扩增法,对８８例乳腺癌和１６例乳腺良性疾病进行端粒酶活性检测。结果８８例乳腺癌中,７５例,检测到端粒酶活性,而在１６例乳腺良性疾病中仅２例端粒酶阳性,两组的差异有显著性。
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| 关 键 词： | 乳腺癌 端粒酶 病理学 TRAP |
Telomerase activity in breast carcinoma |
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| YANG Wentao,XU Liangzhong,ZHANG Taiming,et al.. Telomerase activity in breast carcinoma[J]. Chinese Journal of Oncology, 1999, 21(4): 278-280 |
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| Authors: | YANG Wentao XU Liangzhong ZHANG Taiming et al. |
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| Affiliation: | Laboratory of Molecular Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032. |
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| Abstract: | Objective To investigate the significance of telomerase activity in breast carcinoma with respect to axillary lymph node status. Methods Telomerase activity was analyzed in 88 breast carcinomas specimens and 16 benign breast lesions, using PCR based telomeric repeat amplification protocol (TRAP) assay.Results Telomerase activity was detected in 75 (85.2%) of 88 breast carcinomas (including three breast carcinomas in situ which were all positive for telomerase activity), whereas in benign breast lesions analyzed only 2 (12.5%) of 16 cases were positive ( P <0.001). Besides, telomerase activity was significantly higher in node positive breast carcinomas (93.2%) than in node negative ones (77.3%, P <0 05). Conclusion The results suggest that telomerase activation plays an important role during breast carcinoma progression. It may serve as an early marker of breast carcinoma. |
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| Keywords: | Breast neoplasms/enzymology Breast neoplasms/pathology Telomerase/analysis Telomeric repeat amplification protocol |
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