顺铂加5—氟尿嘧啶联合治疗晚期食管癌156例

目的 观察顺铂＋５－氟尿嘧啶（ＤＤＰ＋５－Ｆｕ）方案治疗食管癌的疗效。方法 中晚期食管癌１５６例,其中２４例除原发灶外别有远处转移,初治１４０例,复治１６例,以ＤＤＰ周期剂量不同分为Ａ,Ｂ两组,两组５－Ｆｕ用量,用法相同,Ａ组ＤＤＰ７５－１００ｍｇ／ｍ＾２,Ｂ组ＤＤＰ５０～７４ｍｇ／ｍ＾２。结果 原发灶肿瘤完全缓解２６例,部分缓解７１例,病情稳定４０例,进展１９例,总有效率６２．２％（９７／１５６

Cisplatin plus 5 fluorouracil combination therapy in the treatment of advanced esophageal cancer: a report of 156 cases

OBJECTIVE: To evaluate the results of combination chemotherapy with cisplatin (DDP) plus 5-fluorouracil(5-FU) in the treatment of advanced esophageal cancer. METHODS: From 1988 through 1997, 156 patients with advanced esophageal cancer were enrolled in this study. The median age of the patients was 60. Squamous-cell cancer was the most common type of malignancy. All but 16 patients received no previous chemotherapy. RESULTS: Complete response was observed in 26 patients and partial response in 71 patients, with an overall response rate of 62.2%. The response appeared to correlate with dose intensity, as 65.7% response rate was achieved with a dose of DDP 75-100 mg/m2 versus 43.7% response rate with DDP 50-70 mg/m2. The median response duration was 4.5 months and the median survival period was 8.2 months. Nausea/vomiting, neutropenia and phlebitis were the main adverse reactions in all treated cases. CONCLUSION: A high response rate was obtained in advanced esophageal cancer treated by DDP plus 5-FU with tolerable toxicity.