| EXPERIMENTAL STUDY ON THE CYTOCIDAL EFFECT OF AT-1840 AND PARVOVIRUS H-1 AGAINST STOMACH CANCER CELLS |
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| 作者姓名： | 吴裕炘 吴云林 余春仙 萧树东 刘炳荣 江绍基 苏兆众 罗祖玉 张素胤 |
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| 作者单位： | Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Institute of Digestive Disease，SSMU，Shanghai，Shanghai Fudan University，Shanghai，Shanghai Fudan University，Shanghai，Shanghai Institute of Materia Medica，Academia Sinica，Shanghai |
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| 摘 要： | We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future.
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EXPERIMENTAL STUDY ON THE CYTOCIDAL EFFECT OF AT-1840 AND PARVOVIRUS H-1 AGAINST STOMACH CANCER CELLS |
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| Wu Yuxin Wu Yunlin Yu Chunxian Xiao Shudong Liu Bingrong Jiang Shaoji.EXPERIMENTAL STUDY ON THE CYTOCIDAL EFFECT OF AT-1840 AND PARVOVIRUS H-1 AGAINST STOMACH CANCER CELLS[J].Journal of Shanghai Second Medical University(Foreign Language Edition),1990(1). |
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| Authors: | Wu Yuxin Wu Yunlin Yu Chunxian Xiao Shudong Liu Bingrong Jiang Shaoji |
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| Institution: | Wu Yuxin Wu Yunlin Yu Chunxian Xiao Shudong Liu Bingrong Jiang Shaoji Shanghai Institute of Digestive Disease,SSMU,Shanghai Su Shaozhong Lu Zuyu Shanghai Fudan University,Shanghai Zhang Suyin Shanghai Institute of Materia Medica,Academia Sinica,Shanghai |
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| Abstract: | We had given evidences of cytocidal effect in vitro of either parvovirus H-I(PV H-1) or AT-1840 (lycobetaine) on gastric cancer cells. They act on different phase of the cell cycle of the gastric cancer cells, with PV H-1 on the late stage of S phase and AT-1840 on M phase. Combined use of these drugs gives better killing effect than the individual drug alone. In gastric cancer-bearing nude mice (ascites and solid tumor forms), both AT-1840 and PV H-1 increased the survival peroids and decreased the size of solid tumors. Depsite these are the experimental study which may not to be the same in human being. However, the study has layed down a solid foundation for our further exploration of these two substances as anti-gastric cancer drugs in the future. |
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| Keywords: | parvovirus H-1 (PV H-1) lycobetaine (AT-1840) cytocidal effect dye exclusion test flow cytometry cancer-bearing nude mice |
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