Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia |
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| Authors: | Takeuchi Seisho Takeuchi Naoko Tsukasaki Kunihiro Bartram Claus R Zimmermann Martin Schrappe Martin Taguchi Hirokuni Koeffler H Phillip |
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| Affiliation: | Division of Hematology/Oncology, Cedars-Sinai Research Institute, UCLA School of Medicine, Los Angeles, USA. takeuti@kochi-ms.ac.jp |
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| Abstract: | ![]()
Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non-Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high-risk haplotype were older than patients with low-risk haplotype (P = 0.024). No statistically significant associations were found between TNF haplotype and sex, WBC counts, central nervous system involvement, immunophenotype, response to chemotherapy, and event-free survival. These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL. |
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| Keywords: | tumour necrosis factor lymphotoxin−α acute lymphoblastic leukaemia polymorphism molecular epidemiology |
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