| 高原红细胞增多症患者红细胞膜ATP酶活性及离子转运功能 |
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| 引用本文： | 邹春华,郑华金,李素芝,薛增军,牟信兵,李木成. 高原红细胞增多症患者红细胞膜ATP酶活性及离子转运功能[J]. 西南国防医药, 1999, 0(6) |
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| 作者姓名： | 邹春华 郑华金 李素芝 薛增军 牟信兵 李木成 |
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| 作者单位： | 成都军区总医院血液科，成都军区总医院血液科，西藏军区总医院高山病研究室，西藏军区总医院高山病研究室，西藏军区总医院高山病研究室，西藏军区总医院高山病研究室 成都 610083，成都 610083 |
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| 摘 要： | 目的:测定26例高原红细胞增多症(HAPC)患者红细胞膜ATP酶活力及红细胞内相关离子浓度,结果:患者红细胞膜Na~ -K~ -ATP酶,Ca~(2 )-ATP酶,Mg~(2 )-ATP酶活性均明显低于正常人(P<0.01),而红细胞内Na~ ,Ca~(2 )浓度却明显高于正常人(P<0.01,P<0.05)。患者红细胞压积与ATP酶活性呈负相关,与红细胞内Na~ 、Ca~(2 )含量呈正相关。提示:高原红细胞增多症细胞代谢异常是机体多系统损害基础。
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| 关 键 词： | 高原红细胞增多症 腺苷三磷酸酶类 离子 |
CHANGES OF ATPase ACTIVITY IN ERYTHROCYTIC MEMBRANCE AND INTRAERY-THROCYTIC IONIC CONCENTRATION IN HIGH ALTITUDE POLYCYTHEMIA PATIENTS |
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| Zhou Chunhua,Li Suzhi,Xue Zengjun,Zheng Huajin,Mu Xinbing,Li Mucheng. CHANGES OF ATPase ACTIVITY IN ERYTHROCYTIC MEMBRANCE AND INTRAERY-THROCYTIC IONIC CONCENTRATION IN HIGH ALTITUDE POLYCYTHEMIA PATIENTS[J]. Medical Journal of National Defending forces in Southwest China, 1999, 0(6) |
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| Authors: | Zhou Chunhua Li Suzhi Xue Zengjun Zheng Huajin Mu Xinbing Li Mucheng |
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| Affiliation: | Zhou Chunhua,Li Suzhi,Xue Zengjun,Zheng Huajin,Mu Xinbing,Li Mucheng Department of high altitude sickness,General Hospital of Tibet Military Command,Lhasa,850003, General Hospital of Chengdu Military Command,Chengdu,610083. |
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| Abstract: | The ATPases' activities in erythrocytic membrance and intraerythrocytic ionic concentration in 26 patients with high altitude polycytheiam (HAPC) were determined. It was found that the activities of Na ,K -ATPase, Ca2 -ATPase and Mg2 - ATPase were significantly lower in HAPC patients than in normal individuals, but the concentrations of Na and Ca2 were obviously higher in HAPC subjects than in the normals. There was a negative correlation between Hct and intraerythrocytic Na concentration in these patients (r = 0. 493,P<0. 05), and a positive correlation between Na , K -ATPase activity and Hct. It is suggested that these changes are related to HAPC occurrence. |
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| Keywords: | high altitude high altitude polycythemia ionenzyme |
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