慢性心力衰竭药物治疗若干进展

导致心力衰竭发生发展的基本机制是心室重塑,当代治疗慢性心力衰竭的关键就是抑制神经内分泌系统过度激活,阻断心室重塑。近年来国内外相继公布了不少有关治疗慢性心力衰竭的循证医学研究结果和诊治指南,本文重点综述血管紧张素转换酶抑制剂、β受体阻滞剂、血管紧张素Ⅱ受体阻滞剂、醛固酮拮抗剂及正性肌力药物在治疗慢性心力衰竭方面的若干进展。

The Progress of Drug Therapy about Chronic Heart Failure

The ventricle remodeling is the basic mechanism resulting in the development of heart failure,the current criticality about its therapy lies in the inhibition of the over activation of neuroendocrine system in order to prevent its ventricle remodeling.Many researches from evidence-based medicine and guidances about diagnosis and treatment related heart failure have been published one after another around exterior and interior in recent years.This article puts the emphasis on the progress of many drugs for the treatment of heart failure including angiotensin converting enzyme inhibitor,β-receptor blocker,blocker of angiotensin;angiotensin Ⅱ receptor,aldosterone antagonists and positive inotropic.