抗环瓜氨酸肽抗体在类风湿关节炎诊断中的应用

目的：了解抗环瓜氨酸肽（CCP）抗体在类风湿关节炎（RA）诊断中的意义.方法：用ELISA方法检测121例RA患者,62例非RA的其他风湿病患者以及50例健康对照组中的抗CCP抗体.结果：121例RA患者中抗CCP抗体的阳性率为66.9%,在非RA的其他风湿病的阳性率是4.8%,健康对照组中的阳性率为0%.抗CCP抗体对RA的敏感性为66.9%,特异性为97.3%.抗CCP抗体阳性组与阴性组相比较,在C-反应蛋白（CRP）、血沉（ESR）和血小板（PLT）方面差异有显著性（P〈0.05）,抗CCP抗体与CRP、ESR、PLT之间存在相关性.结论：抗CCP抗体能用于RA,特别是早期RA的诊断,并且抗CCP抗体对RA的预后有一定的评估作用.

Application of Anti-Cyclic Citrullinated Peptide Antibody Assay in the Diagnosis of Rheumatoid Arthritis

Objctive:To understand the significance of the anti cyclic citrullinated peptide assayin the diagnosis of rheumatoid arthritis.Methods:The anti-CCP was detected in 121 patients with RA,62 other rheumatisants and 50 healthy controlsby ELISA.Result:The positive rates were 66.9% in RA patients and 4.8% in other rheumatisants respectively.The sensitivity and specificity of Anti-CCP for RA were 66.9% and 97.3% respectively. The RA patients with Anti-CCP antibody were significantly different from the patients without antibody in CRP,ESR and PLT(P<(0.05)).Conclusion:Anti-CCP was very significant in the diagnosis of RA,especially early RA.It may possibly be of prognostic value for early RA.