重组人促红细胞生成素对早产儿脑和神经行为发育的影响

目的:了解重组人促红细胞生成素对早产儿脑和神经行为发育的影响。方法:将56例早产儿随机纳入促红细胞生成素治疗组和对照组各28例,治疗组于出生第1周即给rHu-EPO750U.kg-1.w-1,隔日1次,每周3次,共6周,两组均给予维生素K1及补充水、电解质和能量等治疗。矫正胎(年)龄40周、3个月、12个月时两组早产儿均分别进行新生儿行为神经测定(NBNA评分)和神经系统发育评估(婴幼儿智能发育量表)。结果:矫正胎龄40周时,治疗组早产儿行为神经测定得分(39.14±0.51),明显高于对照组(35.10±0.97)(P<0.05);矫正年龄3个月、12个月时,智力发育指数和心理运动发育指数治疗组明显高于对照组(P<0.05)。结论:重组人促红细胞生成素对早产儿脑和神经行为发育可能有促进作用。

Effect of recombinant human erythropoietin on development of brain and neural behavior in premature infants

Objective:To understand the effect of recombinant human erythropoietin on development of brain and neural behavior in premature infants.Methods:56 premature infants were divided into erythropoietin group(n=28)and control group(n=28),the premature infants in erythropoietin group were treated with recombinant human erythropoietin,750 U·kg-1·w-1,once every two days,three times a week for 6 weeks,all the premature infants were treated with vitamin K1,liquid,electrolyte and energy,neonatal neurological score(NBNA score)and assessment of nervous system development(CDCC)were conducted in the two groups on the fortieth gestational age,third month and twelfth month.Results:On the fortieth gestational age,the neonatal neurological score in erythropoietin group was(39.14±0.51),which was significantly higher than that in control group(35.10±0.97)(P<0.05);on the third month and twelfth month,the mental development index and psychomotor development index in erythropoietin group were significantly higher than those in control group(P<0.05).Conclusion:Recombinant human erythropoietin may promote the development of brain and neural behavior in premature infants.