Orientia tsutsugamushi inhibits apoptosis of macrophages by retarding intracellular calcium release |
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| Authors: | Kim Mee-Kyung Seong Seung-Yong Seoh Ju-Young Han Tae-Hee Song Hyeon-Je Lee Ji-Eun Shin Jung-Hoon Lim Byung-Uk Kang Jae-Seung |
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| Affiliation: | Department of Microbiology, Inha University College of Medicine, Inchon 400-103, Republic of Korea. |
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| Abstract: | ![]()
Orientia tsutsugamushi shows both pro- and antiapoptotic activities in infected vertebrate cells. Apoptosis of THP-1 cells induced by beauvericin was inhibited by O. tsutsugamushi infection. Beauvericin-induced calcium redistribution was significantly reduced and retarded in cells infected with O. tsutsugamushi. Antiapoptotic activities of O. tsutsugamushi in infected cells are most probably due to inhibition of the increase in the cytosolic calcium concentration. |
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