三七总皂甙对脑出血患者血清神经元特异性烯醇化酶含量及功能恢复的影响

目的观察三七总皂甙对脑出血患者血清神经元特异性烯醇化酶（NSE）含量及功能恢复的影响，探讨三七总皂甙（PNS）对脑出血的治疗作用。方法选择发病5天内的脑出血患者50例，随机分为PNS组（常规药物治疗加三七总皂甙）27例，对照组（常规药物治疗）23例，采用电化学发光免疫法检测血清NSE含量，美国国立卫生研究院卒中量表（NIHSS）及Barthel指数评分法分别评估神经功能缺损评分及日常生活活动能力评分，观察两组治疗前后血清NSE含量和神经功能恢复情况。结果治疗前两组的血清NSE含量、NIHSS评分、Barthel指数评分之间差异无统计学意义（P〉0．05）。治疗3周后，PNS组的血清NSE含量、NIHSS评分明显低于对照组（P〈0．01）、Barthel指数评分则较对照组高（P〈0．01）。PNS组的血清NSE含量与NIHSS评分呈明显正相关（r=0．757，P〈0．05），与Barthel指数评分显著负相关（r=-0．803，P〈0．05）。结论三七总皂甙有效保护神经细胞，促进功能恢复。

Effect of Panax Notoginseng Saponins on Serum Neuronal Specific Enolase and Rehabilitation in Patients with Cerebral Hemorrhage

ObjectiveTo observe the effect of panax notoginseng saponins(PNS)on serum content of neuronal specific enolase(NSE)and function recovery in patients with cerebral hemorrhage(CH)for exploring the therapeutic action of PNS in treating CH.MethodsFifty CH patients with their course of disease not more than 5 days were randomly assigned to two groups,27 in the PNS group and 23 in the control group,all were treated with conventional treatment,while PNS was given additionally to the PNS group.The serum levels of NSE before and after treatment were determined by electrochemiluminescence,and the recovery of patients,including their neuro-function deficit and daily living activity,was assessed according to scoring by the National Institute of Health Stroke Scale(NIHSS)and Barthel Index(BI)respectively.ResultsBefore treatment,the difference between the two groups in serum NSE content and scores of NIHSS and BI was insignificant(P>0.05).However,after 3 weeks of treatment,the level of NSE and score of NIHSS were significantly lower,while score of BI was significantly higher in the PNS group than those in the control group respectively(all P<0.01).In the PNS group,the level of NSE showed a positive correlation with the score of NIHSS(r=0.757,P<0.05),and a negative correlation with the score of BI(r=-0.803,P<0.05).ConclusionPNS can effectively protect the neuron and promote functional rehabilitation in patients after CH.