胱抑素C与高血压颈动脉IMT的关系研究

目的探讨胱抑素C(Cys C)与原发性高血压患者颈动脉内膜-中层厚度(IMT)的关系。方法选择138例原发性高血压患者,检测患者血清Cys C、生化及血压指标;应用彩色多普勒超声检查仪测定颈动脉IMT,按照颈动脉IMT将原发性高血压患者分为IMT正常组和IMT增厚组,对两组血清Cys C、生化、年龄及血压指标进行比较,并分析上述指标与颈动脉IMT的关系。结果原发性高血压患者IMT增厚组血清Cys C明显高于IMT正常组(1.32±0.42)vs(1.11±0.28)mg/L](t=2.69,P<0.05)。Spearman相关分析发现颈动脉IMT与血清Cys C、年龄显著相关(r=0.398,P<0.01;r=0.512,P<0.01),多元逐步回归分析显示Cys C并非颈动脉IMT的独立危险因素;在调整年龄进行偏相关分析显示Cys C与IMT的相关性差异无统计学意义(r=0.047,P>0.05)。结论血清Cys C与原发性高血压颈动脉IMT无确切关联,不能作为其预测指标。

Correlation between Cystatin C and Carotid Intima-media Thickness in Patients with Hypertension

Objective To investigate the correlation between serum cystatin C and carotid intima-media thickness(IMT) in patients with essential hypertension.Methods One hundred and thirty eight patients with essential hypertension were divided into normal group and abnormal group according to Carotid IMT measured by Doppler ultrasonography;and the serum cystatin C,biochemical indicator and the blood pressure of both groups were detected and compared simultaneously.Results Serum cystatin C levels in abnormal group were higher than that in normal group(1.32±0.42) vs(1.11±0.28) mg/L](t=2.69,P<0.05).On spearman correlation analysis showed that carotid IMT was positively correlated to serum cystatin C and age(r=0.398,P<0.01;r=0.512,P<0.01).The multiple linear regression analysis showed that cystatin C was not the independent risk factor for carotid IMT.After adjustment for age,partial correlation analysis showed that there was no independent association between serum cystatin C level and carotid IMT(r=0.047,P>0.05).Conclusion There is no definite correlation between serum cystatin C and carotid IMT in patients with essential hypertension,and serum cystatin C cannot serve as the indicators for carotid IMT.