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| MAC30蛋白在口腔鳞状细胞癌中的表达及其临床意义 | |
| 引用本文： | 王大维,朱振龙,孙晓峰.MAC30蛋白在口腔鳞状细胞癌中的表达及其临床意义[J].实用口腔医学杂志,2012,28(1):108-110. |
| 作者姓名： | 王大维 朱振龙 孙晓峰 |
| 作者单位： | 1. 050031石家庄,河北医科大学第三医院口腔科; 2. 河北医科大学第一医院病理科 3. 瑞典林雪平大学肿瘤科 |
| 基金项目： | 河北省卫生厅课题(编号:20110416) |
| 摘 要： | 检测20例正常口腔黏膜和43例口腔鳞状细胞癌患者MAC30蛋白的表达情况。MAC30蛋白在口腔鳞状细胞癌中的表达较正常黏膜明显增加(P<0.05);低分化组和淋巴结转移组较高分化组及淋巴结无转移组阳性表达率明显增高(P<0.05);MAC30蛋白在口腔鳞状细胞癌的发生、发展、分化及转移过程中可能起着重要作用,并可作为一个预测肿瘤转移的新的分子生物学指标。 |
| 关 键 词： | 口腔鳞状细胞癌 MAC30蛋白 免疫组织化学 转移 |
Expression of MAC30 protein in oral squamous cell carcinoma and its clinicopathological significance |
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| WANG Dawei , ZHU Zhenlong , SUN Xiaofeng.Expression of MAC30 protein in oral squamous cell carcinoma and its clinicopathological significance[J].Journal of Practical Stomatology,2012,28(1):108-110. | |
| Authors: | WANG Dawei ZHU Zhenlong SUN Xiaofeng |
| Institution: | 1.050031 Shijiazhuang,Department of Stomatology,The Third Hospital of Hebei Medical University,China;2.Department of Pathology,The First Hospital of Hebei Medical University,Shijiazhuang;3.Department of Oncology,Institute of Biomedicine and Surgery,University of Linkǒping,Linkǒping,Sweden |
| Abstract: | MAC30 protein expression was examined by immunohistochemical ABC method in 20 cases of normal oral mucous tissue and 43 cases of oral squamous cell carcinoma(OSCC).MAC30 expression level in OSCC was higher than in normal mucosa(P<0.05).MAC30 expression level in patients with lymph node metastasis and/or with low differentiation was higher than in those without lymph node metastasis and/or with high differentiation(P<0.05).MAC30 may play an important role in the tumorgenesis,development and metastasis of OSCC. |
| Keywords: | OSCC MAC30 protein Immunohistochemistry Metastasis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |