肺炎支原体感染患儿血清IL-17、IL-23表达及临床意义

目的研究肺炎支原体感染患儿血清IL-17、IL-23表达水平变化及临床意义。方法用ELISA法检测肺炎支原体感染患儿血清IL-17、IL-23含量,对MPIgM抗体阳性和MPIgM、IgG抗体同为阳性患儿以及对照组间血清IL-17、IL-23含量比较,对不同临床症状患儿以及对照组血清IL-17、IL-23含量间进行比较,并进行统计学分析。结果 MPIgM抗体阳性和MPIgM、IgG抗体同为阳性患儿血清IL-17、IL-23含量比对照组显著升高(P<0.01),它们之间比较差异也有统计学意义(P<0.01);MP感染患儿中上呼吸道感染、MPP患儿血清IL-17、IL-23含量比对照组显著升高(P<0.01),它们之间比较差异也有统计学意义(P<0.01);MPP中不同临床症状的患儿间血清IL-17、IL-23含量差异有统计学意义(P<0.01)。结论血清IL-17、IL-23含量变化可能促进MP感染患儿的不同临床表现,检测MP感染患儿血清IL-17、IL-23含量对了解疾病的进展和疗效,对MPP治疗有一定的临床意义。

Expression and Clinical Significance of IL-17,IL-23 in Serum of Children with Mycoplasma Pneumoniae Infection

Objective To investigate the expression of IL-17 and IL-23 in the serum of children with mycoplasma pneumonia(MP) infection and its clinical significance.Methods The serum levels of IL-17 and IL-23 in children with mycoplasma pneumoniae infection were detected by ELISA,and the results from patients with positive MPIgM antibody,coincident positive MPIgM and positive IgG antibody,and the control were compared and analyzed statistically.Results The serum levels of IL-17 and IL-23 in children with positive MPIgM antibody or both positive MPIgM and IgG antibody were significantly higher than the control group(P<0.01).The serum levels of IL-17 and IL-23 in children with MP infection or with mycoplasma pneumoniae pneumonia(MPP) were significantly higher than the control group(P<0.01).The serum levels of IL-17 and IL-23 in MPP children with different clinical symptoms were significant different(P<0.01).Conclusion The serum levels of IL-17 and IL-23 may contribute to the different clinical manifestations in children with MP infection.To detect its contents in children with MP infection is helpful for us to understand the development of the disease and the curative efficacy.