探讨注射玻璃酸钠治疗膝关节退行性关节炎的临床疗效分析

目的：分析注射玻璃酸钠治疗膝关节退行性关节炎的临床疗效,探讨其临床适用性。方法选择从2013年3月至2015年3月于本院就诊的61例膝关节退行性关节炎患者,共82只膝关节病变,均采用玻璃酸钠膝关节腔内注射治疗。结果患者治疗后46（56．10％）只膝关节的临床症状和体征完全缓解,33（40．24％）只膝关节的临床症状和体征治疗有效,3（3．66％）只膝关节治疗后临床症状和体征无缓解,治疗无效,总有效率为96．34％。全部患者随访半年,共有5例患者复发,继续关节腔内注射玻璃酸钠治疗后仍有缓解。患者治疗后Lequesne各项症状及体征评分均较治疗前显著升高（P＜0．05）,患者治疗前Lysholm 评分为（55．54±8．26）,治疗后Lysholm 评分为（78．28±8．32）,较治疗前显著升高（t＝17．5641,P＝0．0000）。治疗前患者膝关节屈曲度为（87．9±5．51°）,治疗后膝关节屈曲度为（121．1±5．49°）,较治疗前显著升高（t＝38．6515,P＝0．0000）。患者药物治疗期间未出现显著不良反应。结论玻璃酸钠腔内注射治疗膝关节退行性关节炎临床疗效显著,可以有效改善膝关节的不适症状和体征,增加关节活动度,适合临床长期推广应用。

Analysis of clinical efficacy of sodium hyaluronate injection in the treatment of knee joint degenerative arthritis

Objective To investigate the clinical efficacy of injection of sodium hyaluronate in the treatment of degenerative ar-thritis of the knee joint .Methods 61 cases of patients with degenerative arthritis of the knee were selected from March 2013 to March 2015 in our hospital for treatmentResults The patients with Lequesne scores (symptoms and signs) were significantly high-er than before treatment (P<0 .05) ,before treatment Lysholm score of the patients were 55 .54 ± 8 .26 ,after treatment ,Lysholm score were 78 .28 ± 8 .32 ,significantly higher than before treatment (t=17 .5641 ,P=0 .0000) .Before treatment of knee flexion patients 87 .9 ± 5 .51° ,after treatment of knee flexion was 121 .1 ± 5 .49 ° ,significantly higher than before treatment (t= 38 . 6515 ,P=0 .0000) .No significant adverse reactions occurred during the drug-treated patients .Conclusion Articular injection of so-dium hyaluronate in the treatment of degenerative arthritis of the knee has clinically significant effect ,and is suitable for long-term clinical application .