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Multiple Thromboembolic Events from a Left Atrial Appendage Occlusion Device
Authors:Graeme Prosperi-Porta  Gregory Schnell  Jillian Colbert  Angela Franko  Stephen B. Wilton  Vikas P. Kuriachan
Affiliation:1. Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada;2. Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada;3. Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada
Abstract:
Left atrial appendage occlusion devices are an alternative to oral anticoagulation in patients with nonvalvular atrial fibrillation who are at risk of ischemic stroke. Thromboprophylaxis after implantation is recommended, but the optimal regimen is unknown. We report a clinicopathologic case in which thrombus adherent to an incompletely endothelialized WATCHMAN device (Boston Scientific, Marlborough, MA) resulted in multiple thromboembolic events, contributing to a fatal outcome. This case illustrates uncertainties regarding the device's endothelialization process.
Keywords:Corresponding author: Dr Vikas P. Kuriachan, Foothills Medical Centre, 1403 29th St NW, Calgary, AB T2N 2T9, Canada. Tel.: +1-403-944-3282   fax: +1-403-944-3550.
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