IL-2 receptor {alpha} chain expression during early B lymphocyte differentiation期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

IL-2 receptor {alpha} chain expression during early B lymphocyte differentiation

Authors:	Chen, Jianzhu Ma, Averil Young, Faith Alt, Frederick W.

Affiliation:	Howard Hughes Medical Institute, Children's Hospital, Department of Genetics, Harvard Medical School, and Center for Blood Research 300 Longwood Avenue, Boston, MA 02115, USA

Abstract:	The IL-2/IL-2 receptor (IL-2R) has been studied intensivelybecause of its potential function in the development and regulationof the immune system. The IL-2R ${alpha}$ chain has been shown to be expressedon CD4^–CD8minus; thymocytes and activated T and B cells.In this report, we show that IL-2R ${alpha}$ is also expressed on precursorB cells in the bone marrow. Its expression is initiated by functionalrearrangement and expression of Ig µ heavy chain geneand is down-regulated when immature B cells mature and expressIgD. Its potential function in early B cell differentiationis discussed in comparison with its role in thymocyte differentiation.

Keywords:	activated B cells Ig immature B cells mature B cells pre-B pro-B RAG rearrangement thymocyte differentiation
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