Prognostic value of mitochondrial aspartate aminotransferase in acute myocardial infarction |
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| Authors: | G Annoni R Chirillo D Swannie |
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| Affiliation: | 1. Department of Molecular and Medical Genetics, Knight Diagnostic Laboratories, Oregon Health & Science University, Portland, Oregon, USA;2. College of American Pathologists, Chicago, Illinois, USA;3. GeneDx, Gaithersburg, Maryland, USA;4. Department of Pediatrics, Section of Genetics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA;5. Department of Human Genetics, Clinical Molecular Genetics Laboratory, The University of Chicago, Chicago, Illinois, USA;6. Cytogenetics/Molecular Genetics Laboratory, Nationwide Children’s Hospital, Columbus, Ohio, USA;7. Department of Pathology, Ohio State University College of Medicine, Columbus, Ohio, USA;8. Department of Pediatrics, Ohio State University College of Medicine, Columbus, Ohio, USA;9. Department of Pathology and Laboratory Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA;10. Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, USA;11. Department of Human Genetics, University of California Los Angeles School of Medicine, Los Angeles, California, USA;12. Department of Human Genetics, Emory Genetics Laboratory, Emory University, Atlanta, Georgia, USA;13. Department of Pathology, ARUP Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, Utah, USA;14. Department of Pediatrics, Molecular Genetics Laboratory, Children’s Hospital Colorado, University of Colorado Anschutz Medical School, Denver, Colorado, USA;15. Partners Laboratory for Molecular Medicine and Department of Pathology, Brigham & Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA;16. Current affiliation: Phoenix Children’s Hospital, Phoenix, Arizona, USA |
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| Abstract: | ![]()
In 112 prospectively selected patients suffering from acute myocardial infarction (AMI), the serum CK, CK-MB, LD, HBD, AST and m-AST were determined from the time of admission to hospital and every 12 hours for three days in succession. Sixteen of the enrolled patients died due to complications which arose within the first four days of hospitalization while the rest had a favourable outcome. All enzyme activities were determined at 37 degrees C using routine methods; m-AST was measured using an immunochemical method. The statistical analysis of the results demonstrated that 12 hours after admission, serum m-AST and m-AST/AST ratio were significantly higher in the group of non-survivors compared with patients with a favourable prognosis. No significant differences in CK-MB were observed between survivors and non-survivors during the entire period. True and false positive rates were calculated for these and the other enzymes. An optimum decision level of 34 IU/L was chosen for m-AST and 10% for the m-AST/AST ratio. This gave a percentage of correctly classified patients, after 12 and 24 hours, of 74.9% and 91.9%, respectively. In conclusion, the immunochemical determination of m-AST in patients with AMI seems to be an early prognostic index which is able to distinguish patients with unfavourable outcome. |
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