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| 山西省乙型肝炎病毒基因型别的初步研究 | |
| 引用本文： | 郭瑜,刘晓燕,胡惠梅,陈斯勇,伊瑶,陈向伟,毕胜利. 山西省乙型肝炎病毒基因型别的初步研究[J]. 中华实验和临床病毒学杂志, 2006, 20(4): 361-363 |
| 作者姓名： | 郭瑜 刘晓燕 胡惠梅 陈斯勇 伊瑶 陈向伟 毕胜利 |
| 作者单位： | 1. 100052,北京,中国疾病预防控制中心病毒病预防控制所病毒性肝炎室 2. 山西医科大学 3. 山西省传染病医院 |
| 摘 要： | 目的 初步确定流行于山西地区的乙肝病毒的基因型的基本情况。方法 采集山西地区乙型肝炎表面抗原阳性的血清，利用PCR扩增得到HBV的S基因和C基因；用MEGA3软件对其进行核苷酸序列分析，构建系统发生树，分析基因型。结果 约93％样本的HBVS基因和C基因序列均位于HBV系统发生树的基因型C，近7％的样本其S基因和C基因序列位于系统发生树的基因型B。结论 流行于山西地区的乙肝病毒多数为基因型C，少数为基因型B，未发现基因重组现象。 |
| 关 键 词： | 肝炎病毒 乙型 基因型 |
| 收稿时间： | 2006-02-15 |
| 修稿时间： | 2006-02-15 |
Genotypes of hepatitis B virus in Shanxi province |
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| GUO Yu,LIU Xiao-yan,HU Hui-mei,CHEN Si-yong,YI Yao,CHEN Xiang-wei,BI Sheng-li. Genotypes of hepatitis B virus in Shanxi province[J]. Chinese journal of experimental and clinical virology, 2006, 20(4): 361-363 | |
| Authors: | GUO Yu LIU Xiao-yan HU Hui-mei CHEN Si-yong YI Yao CHEN Xiang-wei BI Sheng-li |
| Affiliation: | Department of Hepatitis Virus, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China |
| Abstract: | Objective To determine the main genotype of hepatitis B virus(HBV)prevailed in Shanxi.Methods Serum specimens were collected from 125 HBsAg positive individuals,and HBV S gene and C gene were obtained by PCR amplifying,and the gene sequences were analyzed and the polygenetic tree was drawn by the software MEGA 3.Results About 93% samples of HBV S gene and C gene clustered in genotype C,about 7% samples clustered at genotype B in the HBV polygenetic tree.Conclusions The main genotype of hepatitis B virus prevalent in Shanxi is genotype C,genotype B is rarely seen,and gene recombination has not been found. |
| Keywords: | Hepatitis B virus Genotype |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |