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Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors
Authors:Jun Li  Julia Koerner  Michael Basler  Thomas Brunner  Christopher J Kirk  Marcus Groettrup
Institution:1. Department of Urology Oncological Surgery, Chongqing University Cancer Hospital, Chongqing Cancer Institute, and Chongqing Cancer Hospital, Chongqing, China;2. Division of Immunology, Department of Biology, University of Konstanz, Konstanz, Germany;3. Biotechnology Institute Thurgau at the University of Konstanz, Kreuzlingen, Switzerland;4. Biochemical Pharmacology, Department of Biology, University of Konstanz, Konstanz, Germany;5. Kezar Life Sciences, South San Francisco, California, USA
Abstract:
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  • Keywords:chronic rejection  immunoproteasome  kidney transplantation  plasma cell  survival niche  unfolded protein response
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