Presynaptic regulation of the release of catecholamines in the cat hypothalamus

The posterior hypothalamus of cats was superfused through a push-pull cannula and the release of endogenous catecholamines was determined in the superfusate. Superfusion with yohimbine, isoprenaline, salbutamol or tazolol increased, while superfusion with propanolol decreased, the release of all three catecholamines. Transection of the brain caudal to the hypothalamus inhibited ‘resting’ and drug-induced release. It is concluded that α- and β-adrenoceptors of the hypothalamus are involved in the regulation of the release of catecholamines.