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| 硫酸沙丁胺醇脉冲微丸释放特性的模型拟合和比较 | |
| 引用本文： | 朱颖,程宁,王雨青,郑梁元. 硫酸沙丁胺醇脉冲微丸释放特性的模型拟合和比较[J]. 中国医药工业杂志, 2006, 37(1): 20-22 |
| 作者姓名： | 朱颖 程宁 王雨青 郑梁元 |
| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016;上海卡乐康包衣技术有限公司,上海,201108 2. 上海卡乐康包衣技术有限公司,上海,201108 3. 上海兴康医药研究开发有限公司,上海,201203 |
| 摘 要： | 比较了用模型拟合法和直接比较法（差异因子法和相似因子法）拟合不同处方硫酸沙朋安醇脉冲微丸体外释放行为的情况。两种方法的拟合结果均表明3种处方微丸的体外释放结果有显著差异。在各数学模型中logistic的拟合效果最好。 |
| 关 键 词： | 释放曲线 模型拟合 差异因子 相似因子 |
| 文章编号： | 1001-8255（2006）01-0020-03 |
| 收稿时间： | 2004-11-30 |
| 修稿时间： | 2004-11-30 |
Model Fitting and Comparison of Dissolution Profiles of Salbutamol Pulsatile Release Pellets |
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| ZHU Ying,CHENG Ning,WANG Yu-Qing,ZHENG Liang-Yuan. Model Fitting and Comparison of Dissolution Profiles of Salbutamol Pulsatile Release Pellets[J]. , 2006, 37(1): 20-22 | |
| Authors: | ZHU Ying CHENG Ning WANG Yu-Qing ZHENG Liang-Yuan |
| Abstract: | The in vitro dissolution profiles of salbutamol pulsatile pellets were fitted and compared by model fittingand model independent methods (difference factor method and similarity factor method). The results of both methodsshowed that the in vitro release of three formulations of salbutamol pulsatile release pellets had significant difference. Thelogistic model was the best one for fitting the dissolution profiles in the several mathematical models. |
| Keywords: | dissolution curve model fitting difference factor similarity factor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |