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| COX-2、Bcl-2基因蛋白在尖锐湿疣组织中的表达及意义 | |
| 引用本文： | 刘启真,陈向敏,叶晓蕾. COX-2、Bcl-2基因蛋白在尖锐湿疣组织中的表达及意义[J]. 浙江医学, 2007, 29(4): 303-304,320 |
| 作者姓名： | 刘启真 陈向敏 叶晓蕾 |
| 作者单位： | 1. 325035,温州医学院生物学实验教学中心 2. 325035,温州医学院环境与公共卫生学院 |
| 基金项目： | 浙江省温州市科技局资助项目 |
| 摘 要： | 目的探讨环氧合酶-2(COX-2)、Bcl-2基因蛋白在尖锐湿疣组织中的表达及意义。方法采用免疫组化SP法对49例尖锐湿疣(CA)组织和26例正常宫颈组织进行COX-2、Bcl-2蛋白检测。结果COX-2、Bcl-2基因蛋白在尖锐湿疣组的表达率和阳性表达程度显著高于正常对照组(P<0.01),但未发现Cox-2与Bcl-2的表达相关(P>0.05)。结论COX-2、Bcl-2基因蛋白表达与CA的发生发展相关,CA的发病可能与Cox-2、Bcl-2基因的阳性表达程度有关。 |
| 关 键 词： | 尖锐湿疣 环氧合酶-2 |
| 修稿时间： | 2006-03-27 |
The expression of COX-2 and Bcl-2 in condyloma acuminatum |
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| LIU Qizhen,CHEN Xiangmin,YE Xiaolei. The expression of COX-2 and Bcl-2 in condyloma acuminatum[J]. Zhejiang Medical Journal, 2007, 29(4): 303-304,320 | |
| Authors: | LIU Qizhen CHEN Xiangmin YE Xiaolei |
| Affiliation: | Teaching Center for Biological Experiments, Wenzhou Medical College, Wenzhou 325035, China |
| Abstract: | Objective To investigate the expressions of COX-2 and Bcl-2 in condyloma acuminatum(CA)and its clinical significance.Methods The expression of COX-2 and Bcl-2 was detected using immuohistochemical staining in 49 specimens of CA,26 specimens of normal cervical tissue.Results The expressive rate and expressive degree of COX-2 and Bcl-2 in CA were significantly higher than those in normal cervical tissue(P<0.005),and the expression of COX-2 was not related to Bcl-2(P>0.005).Conclusion The expression of COX-2 and Bcl-2 seems to be correlated with the occurrence of condyloma acuminatum. |
| Keywords: | Bcl-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |