| 人参总皂甙对14C-花生四烯酸在兔血小板中代谢的影响 |
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| 引用本文： | 京建,金有豫,吴余升,周兴. 人参总皂甙对14C-花生四烯酸在兔血小板中代谢的影响[J]. 药学学报, 1987, 22(3): 166-169 |
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| 作者姓名： | 京建 金有豫 吴余升 周兴 |
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| 作者单位： | 首都医学院药理学教研室 北京(申京建，金有豫)，中国中医研究院西苑医院基础室 北京(吴余升)，中国中医研究院西苑医院基础室 北京(周兴) |
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| 摘 要： | 本文报道人参总皂甙对花生四烯酸在免血小板中代谢的影响。方法采用放射薄层扫描、放射自显影及放射活性测定等同位素技术。结果表明,人参总皂甙抑制兔血小板血栓素A2的生物合成,并呈量效关系。同时对前列腺素A2也有抑制作用。这种抑制怍用的机理,可能是人参总皂甙抑制了血小板环氧酶和血栓素A2合成酶的活性。
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| 关 键 词： | 人参总皂甙 14C-花生四烯酸 血栓素A2 前列腺素A2 |
| 收稿时间： | 1985-10-07 |
EFFECTS OF GINSENG SAPONINS ON 14C-ARACHIDONIC ACID METABOLISM IN RABBIT PLATELETS |
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| SHEN Jing-Jian,JIN You-Yu,WU Yu-Sheng and ZHOU Xing. EFFECTS OF GINSENG SAPONINS ON 14C-ARACHIDONIC ACID METABOLISM IN RABBIT PLATELETS[J]. Acta pharmaceutica Sinica, 1987, 22(3): 166-169 |
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| Authors: | SHEN Jing-Jian JIN You-Yu WU Yu-Sheng ZHOU Xing |
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| Abstract: | The effects of ginseng saponins(GS)on ~(14)C-arachidonic acid metabolism in rabbit platelets were studied with radiochromatography and radioautography The results indicate that the ginseng saponins blocked the biosynthesis of platelet thromboxane A_2 in a dose-dependent manner. Also, the ginseng saponins inhibited the biosynthesis of platelet prostagandin A_2. The mechanism of action of the ginseng saponins was shown to be inhibition of both eyclo-oxygenase and thromboxane synthetase activities. |
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| Keywords: | Ginseng saponins ~(14)C-Arachidonic acid Thromboxane A_2 Prostaglandin A_2 |
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