小儿急性肾炎患者IL-2、IL-6、TNF水平的变化

目的:探讨了小儿急性肾炎患者血清白介素-2(IL-2)、白介素-6(IL-6)、肿瘤坏死因子(TNF)在急性肾炎发生、发展过程中的变化及相互关系。方法:用放射免疫分析检测了31例急性肾炎患儿血清中IL-2、IL-6、TNF水平,并以30例正常健康儿童作比较。结果:急性肾炎患儿血清中IL-6、TNF水平显著高于正常人组(P<0.01),而IL-2水平显著低于正常人组(P<0.01)。直线相关分析显示,IL-6、TNF水平与BUN呈正相关(P<0.01)。结论:血清IL-2、IL-6、TNF在小儿急性肾炎的发生、发展过程中相互作用,观察其浓度的变化对探讨其发病机理及指导用药均有重要临床价值。

Study on the Changes of Serum IL-2,IL-6 and TNF Levels in Pediatric Patients with Acute Nephritis

Objective To investigate the changes of serum IL-2,IL-6 and TNF levels in pediatric patients with acute nephritis. Methods Serum IL-2,IL-6 and TNF levels were measured with RIA in 31 pediatric patients with acute nephritis and 30 controls. Results Serum levels of IL-6,TNF were significantly higher in patients with acute nephritis than those in controls (P<0.01), but serum IL-2 were significantly lower in the patients (P<0.01). Serum IL-6 and TNF levels were positively correlated to BUN levels (P<0.01). Conclusion These cytokines participated in the pathogenesis of acute nephritis in children. Mornitoring the changes of their serum levels was helpful for the management of the disease.