冰片滴鼻对豚鼠鼻粘膜血管和脑血管通透性的影响研究

目的:研究不同浓度冰片滴鼻后对豚鼠鼻粘膜血管和脑血管通透性的影响。方法:将豚鼠随机分为系列浓度冰片(0.5%、1.0%、2.0%)组、组胺组和液体石蜡组,滴鼻给药后静脉注射2%伊文思蓝(EB),10min后处死豚鼠,取鼻粘膜和脑组织,测定并计算鼻粘膜和脑组织中EB含量。结果:与液体石蜡组比较,系列浓度冰片组鼻粘膜和脑组织中EB含量更高(P<0.05或P<0.01),并以2.0%冰片组最为明显。结论:冰片滴鼻可以明显增加豚鼠鼻粘膜血管和脑血管的通透性。

Study on the Effect of Borneol Nasal Drops on the Vasopermeability of Nasal Mucosa and Cerebral Vessel of Guinea Pigs

OBJECTIVE:To observe the effect of different concentration of borneol nasal drops on the vasopermeability of nasal mucosa and the cerebral vessels.METHODS:Guinea pigs were divided into5groups,i.e.borneol group in3different concentrations(0.5%,1.0%and2.0%),histamine group and liquid paraffin group.Guinea pigs were injected i.v with2%evans blue(EB)after administration with nasal drops,which were then put to death10min later;the nasal mucosa and brain tissue of which were obtained and the EB contents in which were determined.RESULTS:Compared with the liquid paraffin group,the EB contents in the nasal mucosa and brain tissue in the borneol groups were higher(P<0.05or P<0.01)with the2.0%borneol group the highest.CONCLUSION:Borneol nasal drops can obviously increase the vasopermeability of nasal mucosa and the cerebral vessels.